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Myosin II contributes to cell-scale actin network treadmilling through network disassembly

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  • Cyrus A. Wilson

    (Stanford University School of Medicine, Stanford, California 94305, USA
    Present addresses: Institute for Creative Technologies, University of Southern California, Marina del Rey, California 90292, USA (C.A.W.); Montreal Neurological Institute, Montreal, Quebec, H3A 2B4, Canada (P.T.Y.); Department of Physics and the Russell Berrie Nanotechnology Institute, Technion – Israel Institute of Technology, Haifa 32000, Israel (K.K.); Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA (G.D.).)

  • Mark A. Tsuchida

    (Stanford University School of Medicine, Stanford, California 94305, USA)

  • Greg M. Allen

    (Stanford University School of Medicine, Stanford, California 94305, USA)

  • Erin L. Barnhart

    (Stanford University School of Medicine, Stanford, California 94305, USA)

  • Kathryn T. Applegate

    (The Scripps Research Institute, La Jolla, California 92037, USA)

  • Patricia T. Yam

    (Stanford University School of Medicine, Stanford, California 94305, USA
    Present addresses: Institute for Creative Technologies, University of Southern California, Marina del Rey, California 90292, USA (C.A.W.); Montreal Neurological Institute, Montreal, Quebec, H3A 2B4, Canada (P.T.Y.); Department of Physics and the Russell Berrie Nanotechnology Institute, Technion – Israel Institute of Technology, Haifa 32000, Israel (K.K.); Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA (G.D.).)

  • Lin Ji

    (The Scripps Research Institute, La Jolla, California 92037, USA)

  • Kinneret Keren

    (Stanford University School of Medicine, Stanford, California 94305, USA
    Present addresses: Institute for Creative Technologies, University of Southern California, Marina del Rey, California 90292, USA (C.A.W.); Montreal Neurological Institute, Montreal, Quebec, H3A 2B4, Canada (P.T.Y.); Department of Physics and the Russell Berrie Nanotechnology Institute, Technion – Israel Institute of Technology, Haifa 32000, Israel (K.K.); Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA (G.D.).)

  • Gaudenz Danuser

    (The Scripps Research Institute, La Jolla, California 92037, USA
    Present addresses: Institute for Creative Technologies, University of Southern California, Marina del Rey, California 90292, USA (C.A.W.); Montreal Neurological Institute, Montreal, Quebec, H3A 2B4, Canada (P.T.Y.); Department of Physics and the Russell Berrie Nanotechnology Institute, Technion – Israel Institute of Technology, Haifa 32000, Israel (K.K.); Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA (G.D.).)

  • Julie A. Theriot

    (Stanford University School of Medicine, Stanford, California 94305, USA
    Stanford University School of Medicine, Stanford, California 94305, USA)

Abstract

Myosin II in cell motility In animals, most cells when on the move migrate using a crawling motion, in which the front of the cell is propelled forward by the force provided by polymerization of actin filaments. Cell biologists have generally assumed that the rear of the crawling cell is then pushed forward by a contractile force generated by non-muscle myosin II. Observations of fish keratocytes in motion now show that no actual contraction is required for rear retraction. Rather, the myosin II has a direct role in facilitating actin network treadmilling via actin disassembly.

Suggested Citation

  • Cyrus A. Wilson & Mark A. Tsuchida & Greg M. Allen & Erin L. Barnhart & Kathryn T. Applegate & Patricia T. Yam & Lin Ji & Kinneret Keren & Gaudenz Danuser & Julie A. Theriot, 2010. "Myosin II contributes to cell-scale actin network treadmilling through network disassembly," Nature, Nature, vol. 465(7296), pages 373-377, May.
    • Handle: RePEc:nat:nature:v:465:y:2010:i:7296:d:10.1038_nature08994
    DOI: 10.1038/nature08994
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    Cited by:

    1. Chao Jiang & Hong-Yu Luo & Xinpeng Xu & Shuo-Xing Dou & Wei Li & Dongshi Guan & Fangfu Ye & Xiaosong Chen & Ming Guo & Peng-Ye Wang & Hui Li, 2023. "Switch of cell migration modes orchestrated by changes of three-dimensional lamellipodium structure and intracellular diffusion," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Xue Zhang & Shishir M. Pant & Cecily C. Ritch & Hsin-Yao Tang & Hongguang Shao & Harsh Dweep & Yao-Yu Gong & Rebekah Brooks & Patricia Brafford & Adam J. Wolpaw & Yool Lee & Ashani Weeraratna & Amita , 2024. "Cell state dependent effects of Bmal1 on melanoma immunity and tumorigenicity," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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