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Moesin integrates cortical and lamellar actin networks during Drosophila macrophage migration

Author

Listed:
  • Besaiz J. Sánchez-Sánchez

    (King’s College London)

  • Stefania Marcotti

    (King’s College London)

  • David Salvador-Garcia

    (King’s College London)

  • María-del-Carmen Díaz-de-la-Loza

    (King’s College London)

  • Mubarik Burki

    (King’s College London)

  • Andrew J. Davidson

    (Bearsden)

  • Will Wood

    (Edinburgh Bioquarter)

  • Brian M. Stramer

    (King’s College London)

Abstract

Cells are thought to adopt mechanistically distinct migration modes depending on cell-type and environmental factors. These modes are assumed to be driven by mutually exclusive actin cytoskeletal organizations, which are either lamellar (flat, branched network) or cortical (crosslinked to the plasma membrane). Here we exploit Drosophila macrophage (hemocyte) developmental dispersal to reveal that these cells maintain both a lamellar actin network at their cell front and a cortical actin network at the rear. Loss of classical actin cortex regulators, such as Moesin, perturb hemocyte morphology and cell migration. Furthermore, cortical and lamellipodial actin networks are interregulated. Upon phosphorylation and binding to the plasma membrane, Moesin is advected to the rear by lamellar actin flow. Simultaneously, the cortical actin network feeds back on the lamella to help regulate actin flow speed and leading-edge dynamics. These data reveal that hemocyte motility requires both lamellipodial and cortical actin architectures in homeostatic equilibrium.

Suggested Citation

  • Besaiz J. Sánchez-Sánchez & Stefania Marcotti & David Salvador-Garcia & María-del-Carmen Díaz-de-la-Loza & Mubarik Burki & Andrew J. Davidson & Will Wood & Brian M. Stramer, 2025. "Moesin integrates cortical and lamellar actin networks during Drosophila macrophage migration," Nature Communications, Nature, vol. 16(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-024-55510-5
    DOI: 10.1038/s41467-024-55510-5
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    References listed on IDEAS

    as
    1. Cyrus A. Wilson & Mark A. Tsuchida & Greg M. Allen & Erin L. Barnhart & Kathryn T. Applegate & Patricia T. Yam & Lin Ji & Kinneret Keren & Gaudenz Danuser & Julie A. Theriot, 2010. "Myosin II contributes to cell-scale actin network treadmilling through network disassembly," Nature, Nature, vol. 465(7296), pages 373-377, May.
    2. Cédric Plutoni & Sarah Keil & Carlos Zeledon & Lara Elis Alberici Delsin & Barbara Decelle & Philippe P. Roux & Sébastien Carréno & Gregory Emery, 2019. "Misshapen coordinates protrusion restriction and actomyosin contractility during collective cell migration," Nature Communications, Nature, vol. 10(1), pages 1-16, December.
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