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Cell signalling by microRNA165/6 directs gene dose-dependent root cell fate

Author

Listed:
  • Annelie Carlsbecker

    (University of Helsinki
    Evolutionary Biology Center, Uppsala University, Norbyvägen 18D, SE-752 36 Uppsala, Sweden)

  • Ji-Young Lee

    (Boyce Thompson Institute for Plant Research, Tower Road, Ithaca, New York 14853, USA
    Graduate Field of Plant Biology, Cornell University, Ithaca, New York 14853, USA)

  • Christina J. Roberts

    (Evolutionary Biology Center, Uppsala University, Norbyvägen 18D, SE-752 36 Uppsala, Sweden)

  • Jan Dettmer

    (University of Helsinki)

  • Satu Lehesranta

    (University of Helsinki)

  • Jing Zhou

    (Boyce Thompson Institute for Plant Research, Tower Road, Ithaca, New York 14853, USA
    Graduate Field of Plant Biology, Cornell University, Ithaca, New York 14853, USA)

  • Ove Lindgren

    (University of Helsinki
    Institute of Technology, University of Tartu)

  • Miguel A. Moreno-Risueno

    (Duke University, Durham, North Carolina 27708, USA)

  • Anne Vatén

    (University of Helsinki)

  • Siripong Thitamadee

    (University of Helsinki)

  • Ana Campilho

    (University of Helsinki)

  • Jose Sebastian

    (Boyce Thompson Institute for Plant Research, Tower Road, Ithaca, New York 14853, USA)

  • John L. Bowman

    (School of Biological Sciences, Monash University, Melbourne, Victoria 3800, Australia)

  • Ykä Helariutta

    (University of Helsinki)

  • Philip N. Benfey

    (Duke University, Durham, North Carolina 27708, USA)

Abstract

A key question in developmental biology is how cells exchange positional information for proper patterning during organ development. In plant roots the radial tissue organization is highly conserved with a central vascular cylinder in which two water conducting cell types, protoxylem and metaxylem, are patterned centripetally. We show that this patterning occurs through crosstalk between the vascular cylinder and the surrounding endodermis mediated by cell-to-cell movement of a transcription factor in one direction and microRNAs in the other. SHORT ROOT, produced in the vascular cylinder, moves into the endodermis to activate SCARECROW. Together these transcription factors activate MIR165a and MIR166b. Endodermally produced microRNA165/6 then acts to degrade its target mRNAs encoding class III homeodomain-leucine zipper transcription factors in the endodermis and stele periphery. The resulting differential distribution of target mRNA in the vascular cylinder determines xylem cell types in a dosage-dependent manner.

Suggested Citation

  • Annelie Carlsbecker & Ji-Young Lee & Christina J. Roberts & Jan Dettmer & Satu Lehesranta & Jing Zhou & Ove Lindgren & Miguel A. Moreno-Risueno & Anne Vatén & Siripong Thitamadee & Ana Campilho & Jose, 2010. "Cell signalling by microRNA165/6 directs gene dose-dependent root cell fate," Nature, Nature, vol. 465(7296), pages 316-321, May.
    • Handle: RePEc:nat:nature:v:465:y:2010:i:7296:d:10.1038_nature08977
    DOI: 10.1038/nature08977
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    Cited by:

    1. Saku T. Kijima & Takema Sasaki & Yuichiro Kikushima & Daisuke Inoue & Shingo Sakamoto & Yuki Kondo & Soichi Inagaki & Masatoshi Yamaguchi & Nobutaka Mitsuda & Yoshihisa Oda, 2025. "Control of plasma membrane-associated actin polymerization specifies the pattern of the cell wall in xylem vessels," Nature Communications, Nature, vol. 16(1), pages 1-18, December.
    2. Mariana Benítez & Jan Hejátko, 2013. "Dynamics of Cell-Fate Determination and Patterning in the Vascular Bundles of Arabidopsis thaliana," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-10, May.

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