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A proximity-based programmable DNA nanoscale assembly line

Author

Listed:
  • Hongzhou Gu

    (New York University, New York, New York 10003, USA)

  • Jie Chao

    (State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Nanjing University)

  • Shou-Jun Xiao

    (State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Nanjing University)

  • Nadrian C. Seeman

    (New York University, New York, New York 10003, USA)

Abstract

Assembly in the nanoworld Many new functional materials and devices could be made if it were possible to rationally combine different nanometre-scale particles into larger structures. An assembly line operating on the nanometre-scale would be an ideal means for constructing a wide range of complex target structures, and has now been demonstrated in proof-of-principle experiments. It combines three known DNA-based modules — a DNA origami tile as framework and track for the assembly process, a cassette providing cargo delivery from three programmable DNA machines, and a three-'handed', four-'footed' DNA walker that generates the target product by moving along the track and collecting cargo as directed by the program. The assembly line can be programmed to join three different types of gold nanoparticle to form eight possible target products.

Suggested Citation

  • Hongzhou Gu & Jie Chao & Shou-Jun Xiao & Nadrian C. Seeman, 2010. "A proximity-based programmable DNA nanoscale assembly line," Nature, Nature, vol. 465(7295), pages 202-205, May.
    • Handle: RePEc:nat:nature:v:465:y:2010:i:7295:d:10.1038_nature09026
    DOI: 10.1038/nature09026
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    Cited by:

    1. Sungwook Woo & Sinem K. Saka & Feng Xuan & Peng Yin, 2024. "Molecular robotic agents that survey molecular landscapes for information retrieval," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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