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An RNA polymerase II- and AGO4-associated protein acts in RNA-directed DNA methylation

Author

Listed:
  • Zhihuan Gao

    (University of California, Riverside, California 92521, USA)

  • Hai-Liang Liu

    (University of California, Riverside, California 92521, USA
    School of life science and technology, Tongji University)

  • Lucia Daxinger

    (Gregor Mendel Institute of Molecular Plant Biology, Austrian Academy of Sciences
    Present address: Division of Genetics and Population Health, Queensland Institute of Medical Research, QLD 4006, Herston, Australia.)

  • Olga Pontes

    (Washington University, St Louis, Missouri 63130, USA)

  • Xinjian He

    (University of California, Riverside, California 92521, USA
    Center for Plant Stress Genomics and Technology, 4700 King Abdullah University of Science and Technology)

  • Weiqiang Qian

    (University of California, Riverside, California 92521, USA)

  • Huixin Lin

    (University of California, Riverside, California 92521, USA)

  • Mingtang Xie

    (University of California, Riverside, California 92521, USA)

  • Zdravko J. Lorkovic

    (Max F. Perutz Laboratory, Medical University of Vienna)

  • Shoudong Zhang

    (University of California, Riverside, California 92521, USA
    Center for Plant Stress Genomics and Technology, 4700 King Abdullah University of Science and Technology)

  • Daisuke Miki

    (University of California, Riverside, California 92521, USA)

  • Xiangqiang Zhan

    (University of California, Riverside, California 92521, USA
    Center for Plant Stress Genomics and Technology, 4700 King Abdullah University of Science and Technology)

  • Dominique Pontier

    (LGDP, CNRS/IRD/Université de Perpignan, UMR 5096, 66860 Perpignan, France)

  • Thierry Lagrange

    (LGDP, CNRS/IRD/Université de Perpignan, UMR 5096, 66860 Perpignan, France)

  • Hailing Jin

    (University of California, Riverside, California 92521, USA)

  • Antonius J. M. Matzke

    (Gregor Mendel Institute of Molecular Plant Biology, Austrian Academy of Sciences)

  • Marjori Matzke

    (Gregor Mendel Institute of Molecular Plant Biology, Austrian Academy of Sciences)

  • Craig S. Pikaard

    (Indiana University, Bloomington, Indiana 47405, USA)

  • Jian-Kang Zhu

    (University of California, Riverside, California 92521, USA
    Center for Plant Stress Genomics and Technology, 4700 King Abdullah University of Science and Technology)

Abstract

RNA-directed DNA methylation in Arabidopsis Small interfering RNAs (siRNAs) are important regulators of gene expression in the plant model Arabidopsis, and intriguingly the vast majority of the small RNAs involved are generated from methylated regions of the genome. A previously unknown protein termed RdDM (for regulator of RNA-directed DNA methylation) has now been identified in Arabidopsis, throwing more light on the interactions of epigenetics, DNA methylation and small RNAs in plants. RDM1 is a novel methyl DNA-binding protein that binds to single-stranded methylated DNA: the many methyl DNA-binding proteins known previously in plants and animals bind only to double-stranded methylated DNA. RDM1 interacts with complexes of the effector protein Argonaute 4 (AGO4) with siRNAs to direct de novo DNA methylation and gene silencing.

Suggested Citation

  • Zhihuan Gao & Hai-Liang Liu & Lucia Daxinger & Olga Pontes & Xinjian He & Weiqiang Qian & Huixin Lin & Mingtang Xie & Zdravko J. Lorkovic & Shoudong Zhang & Daisuke Miki & Xiangqiang Zhan & Dominique , 2010. "An RNA polymerase II- and AGO4-associated protein acts in RNA-directed DNA methylation," Nature, Nature, vol. 465(7294), pages 106-109, May.
    • Handle: RePEc:nat:nature:v:465:y:2010:i:7294:d:10.1038_nature09025
    DOI: 10.1038/nature09025
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    Cited by:

    1. Hong-Wei Zhang & Kun Huang & Zhan-Xi Gu & Xiao-Xian Wu & Jia-Wei Wang & Yu Zhang, 2023. "A cryo-EM structure of KTF1-bound polymerase V transcription elongation complex," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    2. Yujuan Liu & Jie Shu & Zhi Zhang & Ning Ding & Jinyuan Liu & Jun Liu & Yuhai Cui & Changhu Wang & Chen Chen, 2024. "A conserved Pol II elongator SPT6L mediates Pol V transcription to regulate RNA-directed DNA methylation in Arabidopsis," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Zsolt Karányi & Ágnes Mosolygó-L & Orsolya Feró & Adrienn Horváth & Beáta Boros-Oláh & Éva Nagy & Szabolcs Hetey & Imre Holb & Henrik Mihály Szaker & Márton Miskei & Tibor Csorba & Lóránt Székvölgyi, 2022. "NODULIN HOMEOBOX is required for heterochromatin homeostasis in Arabidopsis," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    4. Zheng Li & Ming Wang & Zhenhui Zhong & Javier Gallego-Bartolomé & Suhua Feng & Yasaman Jami-Alahmadi & Xinyi Wang & James Wohlschlegel & Sylvain Bischof & Jeff A. Long & Steven E. Jacobsen, 2023. "The MOM1 complex recruits the RdDM machinery via MORC6 to establish de novo DNA methylation," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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