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Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology

Author

Listed:
  • Sofia Buonocore

    (Sir William Dunn School of Pathology, University of Oxford)

  • Philip P. Ahern

    (Sir William Dunn School of Pathology, University of Oxford)

  • Holm H. Uhlig

    (University Children’s Hospital)

  • Ivaylo I. Ivanov

    (Molecular Pathogenesis Program, Howard Hughes Medical Institute, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA)

  • Dan R. Littman

    (Molecular Pathogenesis Program, Howard Hughes Medical Institute, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA)

  • Kevin J. Maloy

    (Sir William Dunn School of Pathology, University of Oxford)

  • Fiona Powrie

    (Sir William Dunn School of Pathology, University of Oxford
    Translational Gastroenterology Unit, University of Oxford, John Radcliffe Hospital)

Abstract

Innate intestinal inflammatory responses Interleukin 23 (IL-23) has been implicated in the pathogenesis of autoimmune and chronic inflammatory disorders. New work in a mouse model has identified a previously unrecognized population of innate lymphoid cells that respond to IL-23 by inducing inflammation through the production of IL-17 and interferon-γ. Further work will be needed to establish whether this newly discovered IL-23-driven pathway contributes to chronic inflammatory diseases such as irritable bowel disease.

Suggested Citation

  • Sofia Buonocore & Philip P. Ahern & Holm H. Uhlig & Ivaylo I. Ivanov & Dan R. Littman & Kevin J. Maloy & Fiona Powrie, 2010. "Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology," Nature, Nature, vol. 464(7293), pages 1371-1375, April.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7293:d:10.1038_nature08949
    DOI: 10.1038/nature08949
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    Cited by:

    1. Ling Zhang & Yun-bo Wu & Yun-kai Dai & Qi Liu & Yu-jie Ren & Shi-jie Xu & Huai-geng Pan & Wei-jing Chen & Ru-liu Li & Ling Hu, 2021. "Efficacy and safety of Qingre-Chushi therapies in active ulcerative colitis: A network meta-analysis," PLOS ONE, Public Library of Science, vol. 16(9), pages 1-17, September.
    2. Jonathan W. Lo & Jan-Hendrik Schroeder & Luke B. Roberts & Rami Mohamed & Domenico Cozzetto & Gordon Beattie & Omer S. Omer & Ellen M. Ross & Frank Heuts & Geraldine M. Jowett & Emily Read & Matthew M, 2024. "CTLA-4 expressing innate lymphoid cells modulate mucosal homeostasis in a microbiota dependent manner," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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