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IL25 elicits a multipotent progenitor cell population that promotes TH2 cytokine responses

Author

Listed:
  • Steven A. Saenz

    (Department of Pathobiology,)

  • Mark C. Siracusa

    (Department of Pathobiology,)

  • Jacqueline G. Perrigoue

    (Department of Pathobiology,)

  • Sean P. Spencer

    (Department of Pathobiology,)

  • Joseph F. Urban Jr

    (Diet, Genomics, & Immunology Lab, Beltsville Human Nutrition Research Center, Beltsville, Maryland 20705, USA)

  • Joel E. Tocker

    (Amgen, Seattle, Washington 98119, USA)

  • Alison L. Budelsky

    (Amgen, Seattle, Washington 98119, USA)

  • Melanie A. Kleinschek

    (Discovery Research, Schering-Plough Biopharma, Palo Alto, California 94304, USA)

  • Robert A. Kastelein

    (Discovery Research, Schering-Plough Biopharma, Palo Alto, California 94304, USA)

  • Taku Kambayashi

    (University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA)

  • Avinash Bhandoola

    (University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA)

  • David Artis

    (Department of Pathobiology,)

Abstract

Innate immunity: two lines of defence Type-2 immunity, the ancient defence mechanism that provides protection against gastrointestinal helminth infections, involves the recruitment of T helper (TH) cells that produce immune mediators or cytokines to coordinate an immune response involving IgE antibody production, the recruitment of eosinophils and goblet cell hyperplasia. Two groups reporting in this issue have characterized innate type 2 effector leukocyte populations that promote TH2 cytokine responses. Saenz et al. describe multipotent progenitor type-2 (MPPtype2) cells that accumulate in response to the cytokine IL-25 (interleukin-25) and give rise to macrophage or granulocyte lineages promoting TH2 differentiation. Neill et al. describe 'nuocytes', induced by IL25 and IL33, which are the predominant early source of IL13 during a helminth infection. In News & Views, Gérard Eberl discusses how these two papers — and a third in Nature Reviews Immunology ( http://go.nature.com/sJ9D77 ) — influence current thinking on the role of innate immunity.

Suggested Citation

  • Steven A. Saenz & Mark C. Siracusa & Jacqueline G. Perrigoue & Sean P. Spencer & Joseph F. Urban Jr & Joel E. Tocker & Alison L. Budelsky & Melanie A. Kleinschek & Robert A. Kastelein & Taku Kambayash, 2010. "IL25 elicits a multipotent progenitor cell population that promotes TH2 cytokine responses," Nature, Nature, vol. 464(7293), pages 1362-1366, April.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7293:d:10.1038_nature08901
    DOI: 10.1038/nature08901
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    Cited by:

    1. María A. Duque-Correa & David Goulding & Faye H. Rodgers & J. Andrew Gillis & Claire Cormie & Kate A. Rawlinson & Allison J. Bancroft & Hayley M. Bennett & Magda E. Lotkowska & Adam J. Reid & Annelies, 2022. "Defining the early stages of intestinal colonisation by whipworms," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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