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Chromatin signature of embryonic pluripotency is established during genome activation

Author

Listed:
  • Nadine L. Vastenhouw

    (Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA)

  • Yong Zhang

    (Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    School of Life Science and Technology, Tongji University, 1239 Siping Road, Shanghai 200092, China)

  • Ian G. Woods

    (Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA)

  • Farhad Imam

    (Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA)

  • Aviv Regev

    (Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA)

  • X. Shirley Liu

    (Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, Massachusetts 02115, USA)

  • John Rinn

    (Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA)

  • Alexander F. Schier

    (Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Harvard Stem Cell Institute,
    Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA)

Abstract

Chromatin signature of pluripotency To study the changes in chromatin structure that accompany zygotic genome activation and pluripotency during the maternal–zygotic transition (MZT), the genomic locations of histone H3 modifications and RNA polymerase II have been mapped during this transition in zebrafish embryos. H3 lysine 27 trimethylation and H3 lysine 4 trimethylation are only detected after MZT, and evidence is provided that the bivalent chromatin domains in cultured ES cells also exist in embryos.

Suggested Citation

  • Nadine L. Vastenhouw & Yong Zhang & Ian G. Woods & Farhad Imam & Aviv Regev & X. Shirley Liu & John Rinn & Alexander F. Schier, 2010. "Chromatin signature of embryonic pluripotency is established during genome activation," Nature, Nature, vol. 464(7290), pages 922-926, April.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7290:d:10.1038_nature08866
    DOI: 10.1038/nature08866
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    Cited by:

    1. Meijiang Gao & Marina Veil & Marcus Rosenblatt & Aileen Julia Riesle & Anna Gebhard & Helge Hass & Lenka Buryanova & Lev Y. Yampolsky & Björn Grüning & Sergey V. Ulianov & Jens Timmer & Daria Onichtch, 2022. "Pluripotency factors determine gene expression repertoire at zygotic genome activation," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    2. Jiankai Wei & Wei Zhang & An Jiang & Hongzhe Peng & Quanyong Zhang & Yuting Li & Jianqing Bi & Linting Wang & Penghui Liu & Jing Wang & Yonghang Ge & Liya Zhang & Haiyan Yu & Lei Li & Shi Wang & Liang, 2024. "Temporospatial hierarchy and allele-specific expression of zygotic genome activation revealed by distant interspecific urochordate hybrids," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    3. Shifeng Xue & Thanh Thao Nguyen Ly & Raunak S. Vijayakar & Jingyi Chen & Joel Ng & Ajay S. Mathuru & Frederique Magdinier & Bruno Reversade, 2022. "HOX epimutations driven by maternal SMCHD1/LRIF1 haploinsufficiency trigger homeotic transformations in genetically wildtype offspring," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    4. B. Kempisty & D. Bukowska & H. Piotrowska & P. Zawierucha & P. Sniadek & R. Walczak & J. Dziuban & P. Antosik & J. Jaskowski & K.P. Brussow & M. Nowicki & M. Zabel, 2011. "Selected molecular and microfluidic aspects of mammalian oocyte maturation-perspectives: a review," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 56(8), pages 367-378.

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