IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v464y2010i7290d10.1038_nature08866.html
   My bibliography  Save this article

Chromatin signature of embryonic pluripotency is established during genome activation

Author

Listed:
  • Nadine L. Vastenhouw

    (Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA)

  • Yong Zhang

    (Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    School of Life Science and Technology, Tongji University, 1239 Siping Road, Shanghai 200092, China)

  • Ian G. Woods

    (Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA)

  • Farhad Imam

    (Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA)

  • Aviv Regev

    (Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA)

  • X. Shirley Liu

    (Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, Massachusetts 02115, USA)

  • John Rinn

    (Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA)

  • Alexander F. Schier

    (Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Harvard Stem Cell Institute,
    Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA)

Abstract

Chromatin signature of pluripotency To study the changes in chromatin structure that accompany zygotic genome activation and pluripotency during the maternal–zygotic transition (MZT), the genomic locations of histone H3 modifications and RNA polymerase II have been mapped during this transition in zebrafish embryos. H3 lysine 27 trimethylation and H3 lysine 4 trimethylation are only detected after MZT, and evidence is provided that the bivalent chromatin domains in cultured ES cells also exist in embryos.

Suggested Citation

  • Nadine L. Vastenhouw & Yong Zhang & Ian G. Woods & Farhad Imam & Aviv Regev & X. Shirley Liu & John Rinn & Alexander F. Schier, 2010. "Chromatin signature of embryonic pluripotency is established during genome activation," Nature, Nature, vol. 464(7290), pages 922-926, April.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7290:d:10.1038_nature08866
    DOI: 10.1038/nature08866
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature08866
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature08866?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. B. Kempisty & D. Bukowska & H. Piotrowska & P. Zawierucha & P. Sniadek & R. Walczak & J. Dziuban & P. Antosik & J. Jaskowski & K.P. Brussow & M. Nowicki & M. Zabel, 2011. "Selected molecular and microfluidic aspects of mammalian oocyte maturation-perspectives: a review," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 56(8), pages 367-378.
    2. Meijiang Gao & Marina Veil & Marcus Rosenblatt & Aileen Julia Riesle & Anna Gebhard & Helge Hass & Lenka Buryanova & Lev Y. Yampolsky & Björn Grüning & Sergey V. Ulianov & Jens Timmer & Daria Onichtch, 2022. "Pluripotency factors determine gene expression repertoire at zygotic genome activation," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    3. Jiankai Wei & Wei Zhang & An Jiang & Hongzhe Peng & Quanyong Zhang & Yuting Li & Jianqing Bi & Linting Wang & Penghui Liu & Jing Wang & Yonghang Ge & Liya Zhang & Haiyan Yu & Lei Li & Shi Wang & Liang, 2024. "Temporospatial hierarchy and allele-specific expression of zygotic genome activation revealed by distant interspecific urochordate hybrids," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    4. Shifeng Xue & Thanh Thao Nguyen Ly & Raunak S. Vijayakar & Jingyi Chen & Joel Ng & Ajay S. Mathuru & Frederique Magdinier & Bruno Reversade, 2022. "HOX epimutations driven by maternal SMCHD1/LRIF1 haploinsufficiency trigger homeotic transformations in genetically wildtype offspring," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:464:y:2010:i:7290:d:10.1038_nature08866. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.