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Neural mechanisms of ageing and cognitive decline

Author

Listed:
  • Nicholas A. Bishop

    (Harvard Medical School)

  • Tao Lu

    (Harvard Medical School)

  • Bruce A. Yankner

    (Harvard Medical School)

Abstract

During the past century, treatments for the diseases of youth and middle age have helped raise life expectancy significantly. However, cognitive decline has emerged as one of the greatest health threats of old age, with nearly 50% of adults over the age of 85 afflicted with Alzheimer's disease. Developing therapeutic interventions for such conditions demands a greater understanding of the processes underlying normal and pathological brain ageing. Recent advances in the biology of ageing in model organisms, together with molecular and systems-level studies of the brain, are beginning to shed light on these mechanisms and their potential roles in cognitive decline.

Suggested Citation

  • Nicholas A. Bishop & Tao Lu & Bruce A. Yankner, 2010. "Neural mechanisms of ageing and cognitive decline," Nature, Nature, vol. 464(7288), pages 529-535, March.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7288:d:10.1038_nature08983
    DOI: 10.1038/nature08983
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    Citations

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    Cited by:

    1. Sofia Seinfeld & Maria V. Sanchez-Vives, 2015. "Healthy Aging Promotion through Neuroscientific Information-Based Strategies," IJERPH, MDPI, vol. 12(10), pages 1-13, September.
    2. Hsiao-Lan Sharon Wang & Rongjun Yu & Yu-Tzu Wu & Wen-Yuan Lee & Ming-Fan Lin & Chia-Yuan Chen & Ein-Yiao Shen, 2013. "The Changes of Cerebral Morphology Related to Aging in Taiwanese Population," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-6, January.
    3. Filipe Rodrigues & Christophe Domingos & Diogo Monteiro & Pedro Morouço, 2022. "A Review on Aging, Sarcopenia, Falls, and Resistance Training in Community-Dwelling Older Adults," IJERPH, MDPI, vol. 19(2), pages 1-11, January.
    4. Emmanuel A. Ayeni & Ahmad M. Aldossary & Daniel A. Ayejoto & Lanre A. Gbadegesin & Abdullah A. Alshehri & Haya A. Alfassam & Henok K. Afewerky & Fahad A. Almughem & Saidu M. Bello & Essam A. Tawfik, 2022. "Neurodegenerative Diseases: Implications of Environmental and Climatic Influences on Neurotransmitters and Neuronal Hormones Activities," IJERPH, MDPI, vol. 19(19), pages 1-24, September.
    5. Maria Thürmer & André Gollowitzer & Helmut Pein & Konstantin Neukirch & Elif Gelmez & Lorenz Waltl & Natalie Wielsch & René Winkler & Konstantin Löser & Julia Grander & Madlen Hotze & Sönke Harder & A, 2022. "PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    6. Małgorzata Marjańska & Uzay E Emir & Dinesh K Deelchand & Melissa Terpstra, 2013. "Faster Metabolite 1H Transverse Relaxation in the Elder Human Brain," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-1, October.
    7. Jing-Yi Ai & Feng-Tzu Chen & Shu-Shih Hsieh & Shih-Chun Kao & Ai-Guo Chen & Tsung-Min Hung & Yu-Kai Chang, 2021. "The Effect of Acute High-Intensity Interval Training on Executive Function: A Systematic Review," IJERPH, MDPI, vol. 18(7), pages 1-17, March.

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