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Neurodegenerative Diseases: Implications of Environmental and Climatic Influences on Neurotransmitters and Neuronal Hormones Activities

Author

Listed:
  • Emmanuel A. Ayeni

    (Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China
    University of Chinese Academy of Sciences, Beijing 100049, China)

  • Ahmad M. Aldossary

    (National Center of Biotechnology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 12354, Saudi Arabia)

  • Daniel A. Ayejoto

    (Department of Industrial Chemistry, University of Ilorin, Ilorin 240003, Nigeria)

  • Lanre A. Gbadegesin

    (University of Chinese Academy of Sciences, Beijing 100049, China
    Institute of Mountain Hazards and Environment, Chinese Academy of Sciences, Chengdu 610041, China)

  • Abdullah A. Alshehri

    (National Center of Biotechnology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 12354, Saudi Arabia)

  • Haya A. Alfassam

    (KACST-BWH Center of Excellence for Biomedicine, Joint Centers of Excellence Program, King Abdulaziz City for Science and Technology (KACST), Riyadh 12354, Saudi Arabia)

  • Henok K. Afewerky

    (Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China
    School of Allied Health Professions, Asmara College of Health Sciences, Asmara P.O. Box 1220, Eritrea)

  • Fahad A. Almughem

    (National Center of Biotechnology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 12354, Saudi Arabia)

  • Saidu M. Bello

    (Institute of Pharmacognosy, University of Szeged, 6720 Szeged, Hungary)

  • Essam A. Tawfik

    (National Center of Biotechnology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 12354, Saudi Arabia)

Abstract

Neurodegenerative and neuronal-related diseases are major public health concerns. Human vulnerability to neurodegenerative diseases (NDDs) increases with age. Neuronal hormones and neurotransmitters are major determinant factors regulating brain structure and functions. The implications of environmental and climatic changes emerged recently as influence factors on numerous diseases. However, the complex interaction of neurotransmitters and neuronal hormones and their depletion under environmental and climatic influences on NDDs are not well established in the literature. In this review, we aim to explore the connection between the environmental and climatic factors to NDDs and to highlight the available and potential therapeutic interventions that could use to improve the quality of life and reduce susceptibility to NDDs.

Suggested Citation

  • Emmanuel A. Ayeni & Ahmad M. Aldossary & Daniel A. Ayejoto & Lanre A. Gbadegesin & Abdullah A. Alshehri & Haya A. Alfassam & Henok K. Afewerky & Fahad A. Almughem & Saidu M. Bello & Essam A. Tawfik, 2022. "Neurodegenerative Diseases: Implications of Environmental and Climatic Influences on Neurotransmitters and Neuronal Hormones Activities," IJERPH, MDPI, vol. 19(19), pages 1-24, September.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:19:p:12495-:d:930329
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    References listed on IDEAS

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    1. Nicholas A. Bishop & Tao Lu & Bruce A. Yankner, 2010. "Neural mechanisms of ageing and cognitive decline," Nature, Nature, vol. 464(7288), pages 529-535, March.
    2. Frederica Perera, 2017. "Pollution from Fossil-Fuel Combustion is the Leading Environmental Threat to Global Pediatric Health and Equity: Solutions Exist," IJERPH, MDPI, vol. 15(1), pages 1-17, December.
    3. Ian Lahart & Patricia Darcy & Christopher Gidlow & Giovanna Calogiuri, 2019. "The Effects of Green Exercise on Physical and Mental Wellbeing: A Systematic Review," IJERPH, MDPI, vol. 16(8), pages 1-26, April.
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