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Coronary arteries form by developmental reprogramming of venous cells

Author

Listed:
  • Kristy Red-Horse

    (Department of Biochemistry and Howard Hughes Medical Institute,)

  • Hiroo Ueno

    (Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305-5307, USA)

  • Irving L. Weissman

    (Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305-5307, USA)

  • Mark A. Krasnow

    (Department of Biochemistry and Howard Hughes Medical Institute,)

Abstract

Coronary artery disease is the leading cause of death worldwide. Determining the coronary artery developmental program could aid understanding of the disease and lead to new treatments, but many aspects of the process, including their developmental origin, remain obscure. Here we show, using histological and clonal analysis in mice and cardiac organ culture, that coronary vessels arise from angiogenic sprouts of the sinus venosus—the vein that returns blood to the embryonic heart. Sprouting venous endothelial cells dedifferentiate as they migrate over and invade the myocardium. Invading cells differentiate into arteries and capillaries; cells on the surface redifferentiate into veins. These results show that some differentiated venous cells retain developmental plasticity, and indicate that position-specific cardiac signals trigger their dedifferentiation and conversion into coronary arteries, capillaries and veins. Understanding this new reprogramming process and identifying the endogenous signals should suggest more natural ways of engineering coronary bypass grafts and revascularizing the heart.

Suggested Citation

  • Kristy Red-Horse & Hiroo Ueno & Irving L. Weissman & Mark A. Krasnow, 2010. "Coronary arteries form by developmental reprogramming of venous cells," Nature, Nature, vol. 464(7288), pages 549-553, March.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7288:d:10.1038_nature08873
    DOI: 10.1038/nature08873
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    Cited by:

    1. Dorothee Bornhorst & Amulya V. Hejjaji & Lena Steuter & Nicole M. Woodhead & Paul Maier & Alessandra Gentile & Alice Alhajkadour & Octavia Santis Larrain & Michael Weber & Khrievono Kikhi & Stefan Gue, 2024. "The heart is a resident tissue for hematopoietic stem and progenitor cells in zebrafish," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Elena Astanina & Gabriella Doronzo & Davide Corà & Francesco Neri & Salvatore Oliviero & Tullio Genova & Federico Mussano & Emanuele Middonti & Edoardo Vallariello & Chiara Cencioni & Donatella Valdem, 2022. "The TFEB-TGIF1 axis regulates EMT in mouse epicardial cells," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    3. Wei Feng & Abha Bais & Haoting He & Cassandra Rios & Shan Jiang & Juan Xu & Cindy Chang & Dennis Kostka & Guang Li, 2022. "Single-cell transcriptomic analysis identifies murine heart molecular features at embryonic and neonatal stages," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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