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Transcriptional control of preadipocyte determination by Zfp423

Author

Listed:
  • Rana K. Gupta

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Zoltan Arany

    (Harvard Medical School, Boston, Massachusetts 02115, USA
    Present address: Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Massachusetts 02115, USA.)

  • Patrick Seale

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Rina J. Mepani

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Li Ye

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Heather M. Conroe

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Yang A. Roby

    (Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA)

  • Heather Kulaga

    (Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA)

  • Randall R. Reed

    (Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA)

  • Bruce M. Spiegelman

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

Abstract

Zfp423 involved in preadipose cell determination For the past 20 years extensive research from the adipogenesis field has focused almost exclusively on the transcriptional mechanisms governing the differentiation of committed fibroblastic fat cell precursors (preadipocytes) into mature adipocytes. This has led to the identification of a clutch of important regulators of adipocyte differentiation, including PPARγ and various C/EBP family members. Relatively little is known about the transcriptional mechanisms controlling the formation of preadipocytes rather that other fibroblastic cells — the so-called commitment step. Here, the zinc-finger protein Zfp423 is identified as a transcriptional regulator of preadipose cell determination.

Suggested Citation

  • Rana K. Gupta & Zoltan Arany & Patrick Seale & Rina J. Mepani & Li Ye & Heather M. Conroe & Yang A. Roby & Heather Kulaga & Randall R. Reed & Bruce M. Spiegelman, 2010. "Transcriptional control of preadipocyte determination by Zfp423," Nature, Nature, vol. 464(7288), pages 619-623, March.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7288:d:10.1038_nature08816
    DOI: 10.1038/nature08816
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    Cited by:

    1. Sanil Patel & Khatanzul Ganbold & Chung Hwan Cho & Juwairriyyah Siddiqui & Ramazan Yildiz & Njeri Sparman & Shani Sadeh & Christy M. Nguyen & Jiexin Wang & Julian P. Whitelegge & Susan K. Fried & Hiro, 2024. "Transcription factor PATZ1 promotes adipogenesis by controlling promoter regulatory loci of adipogenic factors," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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