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ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C

Author

Listed:
  • Jacques Fellay

    (Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA)

  • Alexander J. Thompson

    (School of Medicine, Duke University, Durham, North Carolina 27705, USA)

  • Dongliang Ge

    (Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA)

  • Curtis E. Gumbs

    (Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA)

  • Thomas J. Urban

    (Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA)

  • Kevin V. Shianna

    (Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA)

  • Latasha D. Little

    (Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA)

  • Ping Qiu

    (Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA)

  • Arthur H. Bertelsen

    (Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA)

  • Mark Watson

    (Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA)

  • Amelia Warner

    (Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA)

  • Andrew J. Muir

    (School of Medicine, Duke University, Durham, North Carolina 27705, USA)

  • Clifford Brass

    (Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA)

  • Janice Albrecht

    (Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA)

  • Mark Sulkowski

    (Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA)

  • John G. McHutchison

    (School of Medicine, Duke University, Durham, North Carolina 27705, USA)

  • David B. Goldstein

    (Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA)

Abstract

Protection against anaemia due to hepatitis C treatments The standard treatment for chronic hepatitis C infection, pegylated interferon (pegIFN) and ribavirin (RBV), carries a range of unpleasant side effects including haemolytic anaemia. Now a genome-wide association study using DNA samples from more than a thousand hepatitis C patients reveals that that genetic variants that lead to inosine triphosphatase deficiency are protective against ribovario-induced haemolytic anaemia. Because inosine triphosphatase deficiency seems to be a benign condition, therapies that target this enzyme could help protect against RBV-induced anaemia. And testing patients for the deficiency could help identify those at risk from this particular side effect.

Suggested Citation

  • Jacques Fellay & Alexander J. Thompson & Dongliang Ge & Curtis E. Gumbs & Thomas J. Urban & Kevin V. Shianna & Latasha D. Little & Ping Qiu & Arthur H. Bertelsen & Mark Watson & Amelia Warner & Andrew, 2010. "ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C," Nature, Nature, vol. 464(7287), pages 405-408, March.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7287:d:10.1038_nature08825
    DOI: 10.1038/nature08825
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    Citations

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    Cited by:

    1. Tarik Asselah & Stefan Zeuzem & Vicente Soriano & Jean-Pierre Bronowicki & Ansgar W Lohse & Beat Müllhaupt & Marcus Schuchmann & Marc Bourlière & Maria Buti & Stuart K Roberts & Edward J Gane & Jerry , 2015. "ITPA Genotypes Predict Anemia but Do Not Affect Virological Response with Interferon-Free Faldaprevir, Deleobuvir, and Ribavirin for HCV Infection," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-13, December.
    2. Verónica Saludes & Elisabet Bascuñana & Elena Jordana-Lluch & Sònia Casanovas & Mercè Ardèvol & Esther Soler & Ramón Planas & Vicente Ausina & Elisa Martró, 2013. "Relevance of Baseline Viral Genetic Heterogeneity and Host Factors for Treatment Outcome Prediction in Hepatitis C Virus 1b-Infected Patients," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-8, August.
    3. Frédégonde About & Tiphaine Oudot-Mellakh & Jonathan Niay & Pascaline Rabiéga & Vincent Pedergnana & Darragh Duffy & Philippe Sultanik & Carole Cagnot & Fabrice Carrat & Patrick Marcellin & Fabien Zou, 2015. "Impact of IL28B, APOH and ITPA Polymorphisms on Efficacy and Safety of TVR- or BOC-Based Triple Therapy in Treatment-Experienced HCV-1 Patients with Compensated Cirrhosis from the ANRS CO20-CUPIC Stud," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-13, December.
    4. Nanye Long & Samuel P Dickson & Jessica M Maia & Hee Shin Kim & Qianqian Zhu & Andrew S Allen, 2013. "Leveraging Prior Information to Detect Causal Variants via Multi-Variant Regression," PLOS Computational Biology, Public Library of Science, vol. 9(6), pages 1-11, June.

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