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CHD7 cooperates with PBAF to control multipotent neural crest formation

Author

Listed:
  • Ruchi Bajpai

    (Department of Chemical and Systems Biology,)

  • Denise A. Chen

    (Department of Chemical and Systems Biology,)

  • Alvaro Rada-Iglesias

    (Department of Chemical and Systems Biology,)

  • Junmei Zhang

    (Protein Chemistry Technology Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA)

  • Yiqin Xiong

    (Department of Medicine, Division of Cardiovascular Medicine,)

  • Jill Helms

    (Department of Surgery,)

  • Ching-Pin Chang

    (Department of Surgery,)

  • Yingming Zhao

    (University of Chicago, Chicago, Illinois 60637, USA)

  • Tomek Swigut

    (Department of Chemical and Systems Biology,)

  • Joanna Wysocka

    (Department of Chemical and Systems Biology,
    Stanford University School of Medicine, Stanford, California 94305, USA)

Abstract

Neural crest abnormalities 'CHARGE syndrome' is a rare congenital condition characterized by malformations of the craniofacial structures, peripheral nervous system, ears, eyes and heart. It is caused by heterozygous mutations in the gene for CHD7, an ATP-dependent chromatin-remodelling protein. It was postulated 25 years ago that CHARGE syndrome results from the abnormal development of the neural crest. This hypothesis has remained untested, but Bajpai et al. now show that CHD7 is essential for the formation of multipotent migratory neural crest, and is essential for activating the neural crest transcriptional circuitry. In addition, CHD7 is shown to cooperate with another chromatin-remodelling complex, PBAF, to promote neural crest gene expression and cell migration.

Suggested Citation

  • Ruchi Bajpai & Denise A. Chen & Alvaro Rada-Iglesias & Junmei Zhang & Yiqin Xiong & Jill Helms & Ching-Pin Chang & Yingming Zhao & Tomek Swigut & Joanna Wysocka, 2010. "CHD7 cooperates with PBAF to control multipotent neural crest formation," Nature, Nature, vol. 463(7283), pages 958-962, February.
    • Handle: RePEc:nat:nature:v:463:y:2010:i:7283:d:10.1038_nature08733
    DOI: 10.1038/nature08733
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    Cited by:

    1. Caojie Liu & Qiuchan Xiong & Qiwen Li & Weimin Lin & Shuang Jiang & Danting Zhang & Yuan Wang & Xiaobo Duan & Ping Gong & Ning Kang, 2022. "CHD7 regulates bone-fat balance by suppressing PPAR-γ signaling," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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