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Chimpanzee and human Y chromosomes are remarkably divergent in structure and gene content

Author

Listed:
  • Jennifer F. Hughes

    (Howard Hughes Medical Institute, Whitehead Institute, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA)

  • Helen Skaletsky

    (Howard Hughes Medical Institute, Whitehead Institute, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA)

  • Tatyana Pyntikova

    (Howard Hughes Medical Institute, Whitehead Institute, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA)

  • Tina A. Graves

    (The Genome Center, Washington University School of Medicine, 4444 Forest Park Boulevard, St Louis, Missouri 63108, USA)

  • Saskia K. M. van Daalen

    (Center for Reproductive Medicine, Academic Medical Center)

  • Patrick J. Minx

    (The Genome Center, Washington University School of Medicine, 4444 Forest Park Boulevard, St Louis, Missouri 63108, USA)

  • Robert S. Fulton

    (The Genome Center, Washington University School of Medicine, 4444 Forest Park Boulevard, St Louis, Missouri 63108, USA)

  • Sean D. McGrath

    (The Genome Center, Washington University School of Medicine, 4444 Forest Park Boulevard, St Louis, Missouri 63108, USA)

  • Devin P. Locke

    (The Genome Center, Washington University School of Medicine, 4444 Forest Park Boulevard, St Louis, Missouri 63108, USA)

  • Cynthia Friedman

    (Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North C3-168, Seattle, Washington 98109, USA)

  • Barbara J. Trask

    (Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North C3-168, Seattle, Washington 98109, USA)

  • Elaine R. Mardis

    (The Genome Center, Washington University School of Medicine, 4444 Forest Park Boulevard, St Louis, Missouri 63108, USA)

  • Wesley C. Warren

    (The Genome Center, Washington University School of Medicine, 4444 Forest Park Boulevard, St Louis, Missouri 63108, USA)

  • Sjoerd Repping

    (Center for Reproductive Medicine, Academic Medical Center)

  • Steve Rozen

    (Howard Hughes Medical Institute, Whitehead Institute, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA)

  • Richard K. Wilson

    (The Genome Center, Washington University School of Medicine, 4444 Forest Park Boulevard, St Louis, Missouri 63108, USA)

  • David C. Page

    (Howard Hughes Medical Institute, Whitehead Institute, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA)

Abstract

The Y factor With the sequencing of the male-specific region of the chimpanzee Y chromosome, it is now possible to make comparisons with the human Y sequence and to learn more about the recent evolution of the human Y chromosome. The two sequences differ markedly in structure and gene content, indicating rapid evolution during the past 6 million years. This finding is at odds with the common view that Y chromosomes are essentially static structures that evolve only very slowly by genetic loss. Rather, renovation and remodelling dominate the evolution of human and chimpanzee Y chromosomes. Possible reasons for this extraordinary divergence include genetic hitchhiking effects, species-specific mating behaviours and the Y chromosome's role in sperm production.

Suggested Citation

  • Jennifer F. Hughes & Helen Skaletsky & Tatyana Pyntikova & Tina A. Graves & Saskia K. M. van Daalen & Patrick J. Minx & Robert S. Fulton & Sean D. McGrath & Devin P. Locke & Cynthia Friedman & Barbara, 2010. "Chimpanzee and human Y chromosomes are remarkably divergent in structure and gene content," Nature, Nature, vol. 463(7280), pages 536-539, January.
    • Handle: RePEc:nat:nature:v:463:y:2010:i:7280:d:10.1038_nature08700
    DOI: 10.1038/nature08700
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    Cited by:

    1. Xuan Li & Sander Visser & Jae Hak Son & Elzemiek Geuverink & Ece Naz Kıvanç & Yanli Wu & Stephan Schmeing & Martin Pippel & Seyed Yahya Anvar & Martijn A. Schenkel & František Marec & Mark D. Robinson, 2024. "Divergent evolution of male-determining loci on proto-Y chromosomes of the housefly," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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