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Divergent evolution of male-determining loci on proto-Y chromosomes of the housefly

Author

Listed:
  • Xuan Li

    (University of Groningen
    Uppsala University)

  • Sander Visser

    (University of Groningen)

  • Jae Hak Son

    (The State University of New Jersey)

  • Elzemiek Geuverink

    (University of Groningen)

  • Ece Naz Kıvanç

    (University of Zürich)

  • Yanli Wu

    (University of Groningen
    University of Göttingen)

  • Stephan Schmeing

    (University of Zürich
    University of Zurich)

  • Martin Pippel

    (Uppsala University)

  • Seyed Yahya Anvar

    (Leiden University Medical Center)

  • Martijn A. Schenkel

    (University of Groningen
    Georgetown University)

  • František Marec

    (Biology Centre of the Czech Academy of Sciences)

  • Mark D. Robinson

    (University of Zürich
    University of Zurich)

  • Richard P. Meisel

    (University of Houston)

  • Ernst A. Wimmer

    (University of Göttingen)

  • Louis van de Zande

    (University of Groningen)

  • Daniel Bopp

    (University of Zürich)

  • Leo W. Beukeboom

    (University of Groningen)

Abstract

Houseflies provide a good experimental model to study the initial evolutionary stages of a primary sex-determining locus because they possess different recently evolved proto-Y chromosomes that contain male-determining loci (M) with the same male-determining gene, Mdmd. We investigate M-loci genomically and cytogenetically revealing distinct molecular architectures among M-loci. M on chromosome V (MV) has two intact Mdmd copies in a palindrome. M on chromosome III (MIII) has tandem duplications containing 88 Mdmd copies (only one intact) and various repeats, including repeats that are XY-prevalent. M on chromosome II (MII) and the Y (MY) share MIII-like architecture, but with fewer repeats. MY additionally shares MV-specific sequence arrangements. Based on these data and karyograms using two probes, one derives from MIII and one Mdmd-specific, we infer evolutionary histories of polymorphic M-loci, which have arisen from unique translocations of Mdmd, embedded in larger DNA fragments, and diverged independently into regions of varying complexity.

Suggested Citation

  • Xuan Li & Sander Visser & Jae Hak Son & Elzemiek Geuverink & Ece Naz Kıvanç & Yanli Wu & Stephan Schmeing & Martin Pippel & Seyed Yahya Anvar & Martijn A. Schenkel & František Marec & Mark D. Robinson, 2024. "Divergent evolution of male-determining loci on proto-Y chromosomes of the housefly," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50390-1
    DOI: 10.1038/s41467-024-50390-1
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    References listed on IDEAS

    as
    1. Jennifer F. Hughes & Helen Skaletsky & Tatyana Pyntikova & Tina A. Graves & Saskia K. M. van Daalen & Patrick J. Minx & Robert S. Fulton & Sean D. McGrath & Devin P. Locke & Cynthia Friedman & Barbara, 2010. "Chimpanzee and human Y chromosomes are remarkably divergent in structure and gene content," Nature, Nature, vol. 463(7280), pages 536-539, January.
    2. Steve Rozen & Helen Skaletsky & Janet D. Marszalek & Patrick J. Minx & Holland S. Cordum & Robert H. Waterston & Richard K. Wilson & David C. Page, 2003. "Abundant gene conversion between arms of palindromes in human and ape Y chromosomes," Nature, Nature, vol. 423(6942), pages 873-876, June.
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