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KAP1 controls endogenous retroviruses in embryonic stem cells

Author

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  • Helen M. Rowe

    (School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland)

  • Johan Jakobsson

    (School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
    Present address: Wallenberg Neuroscience Center, Department of Experimental Medical Sciences, Lund University, 22184 Lund, Sweden.)

  • Daniel Mesnard

    (School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland)

  • Jacques Rougemont

    (School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland)

  • Séverine Reynard

    (School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland)

  • Tugce Aktas

    (EMBL Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany)

  • Pierre V. Maillard

    (School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland)

  • Hillary Layard-Liesching

    (School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland)

  • Sonia Verp

    (School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland)

  • Julien Marquis

    (School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland)

  • François Spitz

    (EMBL Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany)

  • Daniel B. Constam

    (School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland)

  • Didier Trono

    (School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland)

Abstract

Endogenous retroviruses in embryonic stem cells Almost half of the mammalian genome is derived from virus-like entities called retroelements, many of them the result of the incorporation of endogenous retroviruses. Didier Trono and colleagues use a combination of genetic, functional and biochemical analyses to demonstrate that KRAB-associated protein 1 (KAP1)-mediated epigenetic regulation is involved in the early embryonic silencing of intracisternal A particles (IAPs), a still active and highly polymorphic subset of endogenous retroviruses. This work establishes a role for the KAP1 co-repressor in the control of endogenous retroelements during early embryonic development.

Suggested Citation

  • Helen M. Rowe & Johan Jakobsson & Daniel Mesnard & Jacques Rougemont & Séverine Reynard & Tugce Aktas & Pierre V. Maillard & Hillary Layard-Liesching & Sonia Verp & Julien Marquis & François Spitz & D, 2010. "KAP1 controls endogenous retroviruses in embryonic stem cells," Nature, Nature, vol. 463(7278), pages 237-240, January.
    • Handle: RePEc:nat:nature:v:463:y:2010:i:7278:d:10.1038_nature08674
    DOI: 10.1038/nature08674
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    Cited by:

    1. Duomeng Yang & Tingting Geng & Andrew G. Harrison & Jason G. Cahoon & Jian Xing & Baihai Jiao & Mark Wang & Chao Cheng & Robert E. Hill & Huadong Wang & Anthony T. Vella & Gong Cheng & Yanlin Wang & P, 2024. "UBR5 promotes antiviral immunity by disengaging the transcriptional brake on RIG-I like receptors," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Sophia Groh & Anna Viktoria Milton & Lisa Katherina Marinelli & Cara V. Sickinger & Angela Russo & Heike Bollig & Gustavo Pereira de Almeida & Andreas Schmidt & Ignasi Forné & Axel Imhof & Gunnar Scho, 2021. "Morc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    3. Sarah Tessier & Omar Ferhi & Marie-Claude Geoffroy & Román González-Prieto & Antoine Canat & Samuel Quentin & Marika Pla & Michiko Niwa-Kawakita & Pierre Bercier & Domitille Rérolle & Marilyn Tirard &, 2022. "Exploration of nuclear body-enhanced sumoylation reveals that PML represses 2-cell features of embryonic stem cells," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. Phoebe Lut Fei Tam & Ming Fung Cheung & Lu Yan Chan & Danny Leung, 2024. "Cell-type differential targeting of SETDB1 prevents aberrant CTCF binding, chromatin looping, and cis-regulatory interactions," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    5. Kentaro Mochizuki & Jafar Sharif & Kenjiro Shirane & Kousuke Uranishi & Aaron B. Bogutz & Sanne M. Janssen & Ayumu Suzuki & Akihiko Okuda & Haruhiko Koseki & Matthew C. Lorincz, 2021. "Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    6. Poonam Dhillon & Kelly Ann Mulholland & Hailong Hu & Jihwan Park & Xin Sheng & Amin Abedini & Hongbo Liu & Allison Vassalotti & Junnan Wu & Katalin Susztak, 2023. "Increased levels of endogenous retroviruses trigger fibroinflammation and play a role in kidney disease development," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    7. Fabrice P A David & Julien Delafontaine & Solenne Carat & Frederick J Ross & Gregory Lefebvre & Yohan Jarosz & Lucas Sinclair & Daan Noordermeer & Jacques Rougemont & Marion Leleu, 2014. "HTSstation: A Web Application and Open-Access Libraries for High-Throughput Sequencing Data Analysis," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-9, January.
    8. Nadine Born & Hans-Jürgen Thiesen & Peter Lorenz, 2014. "The B-Subdomain of the Xenopus laevis XFIN KRAB-AB Domain Is Responsible for Its Weaker Transcriptional Repressor Activity Compared to Human ZNF10/Kox1," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-15, February.
    9. Eckhard Limpert & Werner A Stahel, 2011. "Problems with Using the Normal Distribution – and Ways to Improve Quality and Efficiency of Data Analysis," PLOS ONE, Public Library of Science, vol. 6(7), pages 1-8, July.
    10. Hua Yu & Zhen Sun & Tianyu Tan & Hongru Pan & Jing Zhao & Ling Zhang & Jiayu Chen & Anhua Lei & Yuqing Zhu & Lang Chen & Yuyan Xu & Yaxin Liu & Ming Chen & Jinghao Sheng & Zhengping Xu & Pengxu Qian &, 2021. "rRNA biogenesis regulates mouse 2C-like state by 3D structure reorganization of peri-nucleolar heterochromatin," Nature Communications, Nature, vol. 12(1), pages 1-21, December.

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