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An allosteric mechanism of Rho-dependent transcription termination

Author

Listed:
  • Vitaly Epshtein

    (New York University School of Medicine, New York, New York 10016, USA)

  • Dipak Dutta

    (New York University School of Medicine, New York, New York 10016, USA)

  • Joseph Wade

    (School of Public Health, University at Albany, Albany, New York 12201, USA)

  • Evgeny Nudler

    (New York University School of Medicine, New York, New York 10016, USA)

Abstract

Mechanism of Rho-dependent termination of transcription Rho is a general transcription termination factor in bacteria, but the mechanism by which it disrupts the RNA polymerase (RNAP) elongation complex is unknown. Here, Rho is shown to bind tightly to RNAP throughout the transcription cycle, and RNAP is proposed to have an active function in Rho termination through an allosteric mechanism. The overall structure of elongation complexes has been preserved during evolution, from bacteria to humans, suggesting that this allosteric control mechanism may a characteristic of transcription systems in general.

Suggested Citation

  • Vitaly Epshtein & Dipak Dutta & Joseph Wade & Evgeny Nudler, 2010. "An allosteric mechanism of Rho-dependent transcription termination," Nature, Nature, vol. 463(7278), pages 245-249, January.
    • Handle: RePEc:nat:nature:v:463:y:2010:i:7278:d:10.1038_nature08669
    DOI: 10.1038/nature08669
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    Cited by:

    1. Britney Martinez & Binod K. Bharati & Vitaly Epshtein & Evgeny Nudler, 2022. "Pervasive Transcription-coupled DNA repair in E. coli," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    2. Eunho Song & Heesoo Uhm & Palinda Ruvan Munasingha & Seungha Hwang & Yeon-Soo Seo & Jin Young Kang & Changwon Kang & Sungchul Hohng, 2022. "Rho-dependent transcription termination proceeds via three routes," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Jing Zhang & Shuo Zhang & Wei Zhou & Xiang Zhang & Guanjin Li & Ruoxuan Li & Xingyu Lin & Ziying Chen & Fang Liu & Pan Shen & Xiaogen Zhou & Yue Gao & Zhenguo Chen & Yanjie Chao & Chengyuan Wang, 2024. "A widely conserved protein Rof inhibits transcription termination factor Rho and promotes Salmonella virulence program," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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