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The Dbf4–Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4

Author

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  • Yi-Jun Sheu

    (Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA)

  • Bruce Stillman

    (Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA)

Abstract

Dual function of Dbf4–Cdc7 kinase Two cell-cycle-regulated kinase pathways regulate the timing of DNA replication initiation. How one of these, the Dbf4–Cdc7 kinase (DDK), affects replication has been unclear. Yi-Jun Sheu and Bruce Stillman now show that a subunit of the replicative helicase, Mcm4, is the target of DDK. The N-terminal domain of Mcm4 possesses an inhibitory activity that is relieved by DDK phosphorylation. In addition, DDK activity also seems to have a second function in regulating the S-phase checkpoint.

Suggested Citation

  • Yi-Jun Sheu & Bruce Stillman, 2010. "The Dbf4–Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4," Nature, Nature, vol. 463(7277), pages 113-117, January.
    • Handle: RePEc:nat:nature:v:463:y:2010:i:7277:d:10.1038_nature08647
    DOI: 10.1038/nature08647
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    Cited by:

    1. Aftab Amin & Cheung Man Hei & Chun Liang & Aftab Amin & Cheung Man Hei & Chun Liang & Chun Liang & Aftab Amin & Cheung Man Hei & Chun Liang, 2019. "DNA Replication-Initiation Proteins in Eukaryotic Cells," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 22(5), pages 17042-17049, December.
    2. Almutasem Saleh & Yasunori Noguchi & Ricardo Aramayo & Marina E. Ivanova & Kathryn M. Stevens & Alex Montoya & S. Sunidhi & Nicolas Lopez Carranza & Marcin J. Skwark & Christian Speck, 2022. "The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    3. Lorenzo Galanti & Martina Peritore & Robert Gnügge & Elda Cannavo & Johannes Heipke & Maria Dilia Palumbieri & Barbara Steigenberger & Lorraine S. Symington & Petr Cejka & Boris Pfander, 2024. "Dbf4-dependent kinase promotes cell cycle controlled resection of DNA double-strand breaks and repair by homologous recombination," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    4. Jiaxuan Cheng & Ningning Li & Yunjing Huo & Shangyu Dang & Bik-Kwoon Tye & Ning Gao & Yuanliang Zhai, 2022. "Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    5. Karl-Uwe Reusswig & Julia Bittmann & Martina Peritore & Mathilde Courtes & Benjamin Pardo & Michael Wierer & Matthias Mann & Boris Pfander, 2022. "Unscheduled DNA replication in G1 causes genome instability and damage signatures indicative of replication collisions," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

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