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Dynamic activation of an allosteric regulatory protein

Author

Listed:
  • Shiou-Ru Tzeng

    (Department of Chemistry & Chemical Biology,
    Rutgers University, Piscataway, New Jersey 08854, USA)

  • Charalampos G. Kalodimos

    (Department of Chemistry & Chemical Biology,
    Rutgers University, Piscataway, New Jersey 08854, USA)

Abstract

Allostery goes dynamic Effector molecules are thought to control the activity of allosteric proteins by binding to an allosteric site, distinct from the active site, thereby inducing and stabilizing a specific conformational state of the protein. A new study suggests that the notion of purely structurally regulated activity in allosteric proteins should be revised to include a frequently dominating contribution from protein dynamics. Shiou-Ru Tzeng and Charalampos Kalodimos characterized cyclic AMP binding to catabolite activator protein (CAP), a transcriptional activator often used as a model for allostery. They find, surprisingly, that even when in a structurally inactive conformation, CAP can be activated for ligand (DNA) binding by changes in protein dynamics.

Suggested Citation

  • Shiou-Ru Tzeng & Charalampos G. Kalodimos, 2009. "Dynamic activation of an allosteric regulatory protein," Nature, Nature, vol. 462(7271), pages 368-372, November.
    • Handle: RePEc:nat:nature:v:462:y:2009:i:7271:d:10.1038_nature08560
    DOI: 10.1038/nature08560
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    Cited by:

    1. Anna C. Papageorgiou & Michaela Pospisilova & Jakub Cibulka & Raghib Ashraf & Christopher A. Waudby & Pavel Kadeřávek & Volha Maroz & Karel Kubicek & Zbynek Prokop & Lumir Krejci & Konstantinos Tripsi, 2023. "Recognition and coacervation of G-quadruplexes by a multifunctional disordered region in RECQ4 helicase," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Federica Maschietto & Uriel N. Morzan & Florentina Tofoleanu & Aria Gheeraert & Apala Chaudhuri & Gregory W. Kyro & Peter Nekrasov & Bernard Brooks & J. Patrick Loria & Ivan Rivalta & Victor S. Batist, 2023. "Turning up the heat mimics allosteric signaling in imidazole-glycerol phosphate synthase," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Yuan Liang & Yunkai Qie & Jing Yang & Ranfeng Wu & Shuang Cui & Yuliang Zhao & Greg J. Anderson & Guangjun Nie & Suping Li & Cheng Zhang, 2023. "Programming conformational cooperativity to regulate allosteric protein-oligonucleotide signal transduction," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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