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A regulatory circuit for piwi by the large Maf gene traffic jam in Drosophila

Author

Listed:
  • Kuniaki Saito

    (Keio University School of Medicine)

  • Sachi Inagaki

    (Keio University School of Medicine)

  • Toutai Mituyama

    (Computational Biology Research Center (CBRC), National Institute of Advanced Industrial Science and Technology (AIST))

  • Yoshinori Kawamura

    (Keio University School of Medicine
    Institute of Health Biosciences University of Tokushima)

  • Yukiteru Ono

    (Information and Mathematical Science Laboratory, Inc.)

  • Eri Sakota

    (Japan Biological Informatics Consortium (JBIC))

  • Hazuki Kotani

    (Keio University School of Medicine)

  • Kiyoshi Asai

    (Computational Biology Research Center (CBRC), National Institute of Advanced Industrial Science and Technology (AIST)
    Graduate School of Frontier Sciences, University of Tokyo)

  • Haruhiko Siomi

    (Keio University School of Medicine)

  • Mikiko C. Siomi

    (Keio University School of Medicine
    JST, CREST)

Abstract

A regulatory circuit for Piwi A class of small RNAs, piRNAs, interact with PIWI domain-containing Argonaute proteins. Germline piRNAs derive from repetitive DNA and are produced by an amplification process. Recently piRNAs have also been found to be encoded by protein-coding genes in somatic cells. In this work, Siomi and colleagues show that the traffic jam (tj) locus, encoding the Maf transcription factor, encodes a piRNA cluster. These piRNAs are produced in the cytoplasm without amplification, and target FasIII for silencing. Maf itself activates Piwi expression. Thus, the tj locus encodes both an enhancer of Piwi and the piRNAs that interact with Piwi.

Suggested Citation

  • Kuniaki Saito & Sachi Inagaki & Toutai Mituyama & Yoshinori Kawamura & Yukiteru Ono & Eri Sakota & Hazuki Kotani & Kiyoshi Asai & Haruhiko Siomi & Mikiko C. Siomi, 2009. "A regulatory circuit for piwi by the large Maf gene traffic jam in Drosophila," Nature, Nature, vol. 461(7268), pages 1296-1299, October.
    • Handle: RePEc:nat:nature:v:461:y:2009:i:7268:d:10.1038_nature08501
    DOI: 10.1038/nature08501
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    Cited by:

    1. Yu H. Sun & Ruoqiao Huiyi Wang & Khai Du & Jiang Zhu & Jihong Zheng & Li Huitong Xie & Amanda A. Pereira & Chao Zhang & Emiliano P. Ricci & Xin Zhiguo Li, 2021. "Coupled protein synthesis and ribosome-guided piRNA processing on mRNAs," Nature Communications, Nature, vol. 12(1), pages 1-19, December.
    2. Shihui Chen & Carolyn M. Phillips, 2024. "HRDE-2 drives small RNA specificity for the nuclear Argonaute protein HRDE-1," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    3. Shunya Kaneko & Keita Miyoshi & Kotaro Tomuro & Makoto Terauchi & Ryoya Tanaka & Shu Kondo & Naoki Tani & Kei-Ichiro Ishiguro & Atsushi Toyoda & Azusa Kamikouchi & Hideki Noguchi & Shintaro Iwasaki & , 2024. "Mettl1-dependent m7G tRNA modification is essential for maintaining spermatogenesis and fertility in Drosophila melanogaster," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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