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Robust discrimination between self and non-self neurites requires thousands of Dscam1 isoforms

Author

Listed:
  • Daisuke Hattori

    (Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA)

  • Yi Chen

    (Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA)

  • Benjamin J. Matthews

    (Center for Neurobiology and Behavior, Columbia University Medical Center, New York, New York 10032, USA)

  • Lukasz Salwinski

    (UCLA-DOE Institute for Genomics and Proteomics, Howard Hughes Medical Institute, Molecular Biology Institute, Los Angeles, California 90095, USA)

  • Chiara Sabatti

    (David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA)

  • Wesley B. Grueber

    (Columbia University Medical Center, New York, New York 10032, USA)

  • S. Lawrence Zipursky

    (Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA)

Abstract

Discriminating neurites need multiple Dscam1 isoforms In fruitfly nerve cells, alternative splicing of the Dscam gene's messenger RNA produces a remarkable variety of cell-surface proteins — presenting some 19,000 different extracellular domains. Each isoform is capable of binding exclusively to itself, thus promoting repulsion among neuronal processes extended by the same neuron. This process of neurite self-avoidance is important in helping to direct dendritic and axonal branching appropriately. By generating mutant flies with graded reductions in the number of Dscam isoforms, Larry Zipursky and his team have now determined that at least 1,000 but no more than 5,000 isoforms are essential to provide a robust mechanism of neuronal self-avoidance during brain wiring. How this translates into vertebrate brain development remains unclear, as vertebrate Dscam genes produce just a handful of distinct isoforms.

Suggested Citation

  • Daisuke Hattori & Yi Chen & Benjamin J. Matthews & Lukasz Salwinski & Chiara Sabatti & Wesley B. Grueber & S. Lawrence Zipursky, 2009. "Robust discrimination between self and non-self neurites requires thousands of Dscam1 isoforms," Nature, Nature, vol. 461(7264), pages 644-648, October.
    • Handle: RePEc:nat:nature:v:461:y:2009:i:7264:d:10.1038_nature08431
    DOI: 10.1038/nature08431
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    Cited by:

    1. Jie Cheng & Yamei Yu & Xingyu Wang & Xi Zheng & Ting Liu & Daojun Hu & Yongfeng Jin & Ying Lai & Tian-Min Fu & Qiang Chen, 2023. "Structural basis for the self-recognition of sDSCAM in Chelicerata," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Jianfei Hu & Eli Boritz & William Wylie & Daniel C Douek, 2017. "Stochastic principles governing alternative splicing of RNA," PLOS Computational Biology, Public Library of Science, vol. 13(9), pages 1-20, September.

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