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Selective epigenetic control of retrotransposition in Arabidopsis

Author

Listed:
  • Marie Mirouze

    (University of Geneva, Sciences III, 30 Quai Ernest-Ansermet, CH-1211 Geneva 4, Switzerland)

  • Jon Reinders

    (University of Geneva, Sciences III, 30 Quai Ernest-Ansermet, CH-1211 Geneva 4, Switzerland)

  • Etienne Bucher

    (University of Geneva, Sciences III, 30 Quai Ernest-Ansermet, CH-1211 Geneva 4, Switzerland)

  • Taisuke Nishimura

    (University of Geneva, Sciences III, 30 Quai Ernest-Ansermet, CH-1211 Geneva 4, Switzerland)

  • Korbinian Schneeberger

    (Max Planck Institute for Developmental Biology)

  • Stephan Ossowski

    (Max Planck Institute for Developmental Biology)

  • Jun Cao

    (Max Planck Institute for Developmental Biology)

  • Detlef Weigel

    (Max Planck Institute for Developmental Biology)

  • Jerzy Paszkowski

    (University of Geneva, Sciences III, 30 Quai Ernest-Ansermet, CH-1211 Geneva 4, Switzerland)

  • Olivier Mathieu

    (University of Geneva, Sciences III, 30 Quai Ernest-Ansermet, CH-1211 Geneva 4, Switzerland
    Centre National de la Recherche Scientifique (CNRS), UMR 6247, GReD, INSERM U 931, 24 avenue des Landais, Clermont Université)

Abstract

Genome structure: controlled retrotransposition Retrotransposons are mobile genetic elements constituting above 40 and 60% of the human and maize genomes, respectively, and their activity is thought to accelerate the evolution of host chromosomes. To disperse through the genome, retrotransposons must first be transcribed into RNA. The methylation of DNA prevents transcription, and is a means by which retrotransposon movement is suppressed. Tsukahara et al. show that in Arabidopsis plants with defective DNA methylation, several types of retrotransposon are activated, and frequently target to the centromeric DNA, which is presumably less harmful than insertion into genes. In a second study, Mirouze et al. also looked at retrotransposition in Arabidopsis. They report that although DNA methylation is associated with the suppression of transposon-derived transcriptions, transposition remains suppressed after transcriptional reactivation due to the epigenetic activity of a plant-specific RNA polymerase, pol IV/V, and a histone methyltransferase, KYP. This mechanism appears to be specific for a particular element known as Évadé — which is a member of the ATCOPIA93 family and is related to one of the four long terminal repeat (LTR) retrotransposons described by Tsukahara et al.

Suggested Citation

  • Marie Mirouze & Jon Reinders & Etienne Bucher & Taisuke Nishimura & Korbinian Schneeberger & Stephan Ossowski & Jun Cao & Detlef Weigel & Jerzy Paszkowski & Olivier Mathieu, 2009. "Selective epigenetic control of retrotransposition in Arabidopsis," Nature, Nature, vol. 461(7262), pages 427-430, September.
    • Handle: RePEc:nat:nature:v:461:y:2009:i:7262:d:10.1038_nature08328
    DOI: 10.1038/nature08328
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    Cited by:

    1. Li He & Huan Huang & Mariem Bradai & Cheng Zhao & Yin You & Jun Ma & Lun Zhao & Rosa Lozano-Durán & Jian-Kang Zhu, 2022. "DNA methylation-free Arabidopsis reveals crucial roles of DNA methylation in regulating gene expression and development," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Panpan Zhang & Assane Mbodj & Abirami Soundiramourtty & Christel Llauro & Alain Ghesquière & Mathieu Ingouff & R. Keith Slotkin & Frédéric Pontvianne & Marco Catoni & Marie Mirouze, 2023. "Extrachromosomal circular DNA and structural variants highlight genome instability in Arabidopsis epigenetic mutants," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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