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Surface hydrophobin prevents immune recognition of airborne fungal spores

Author

Listed:
  • Vishukumar Aimanianda

    (Unité des Aspergillus, Institut Pasteur)

  • Jagadeesh Bayry

    (INSERM, U 872,
    Centre de Recherche des Cordeliers, Université Pierre et Marie Curie–Paris 6, UMR S 872,
    Université Paris Descartes, UMR S 872, Paris F-75006, France)

  • Silvia Bozza

    (Department of Experimental Medicine and Biochemical Sciences,)

  • Olaf Kniemeyer

    (Leibniz-Institute for Natural Product Research and Infection Biology (HKI) and Friedrich Schiller University)

  • Katia Perruccio

    (Clinical Immunology, University of Perugia, Perugia 06122, Italy)

  • Sri Ramulu Elluru

    (INSERM, U 872,
    Centre de Recherche des Cordeliers, Université Pierre et Marie Curie–Paris 6, UMR S 872,
    Université Paris Descartes, UMR S 872, Paris F-75006, France)

  • Cécile Clavaud

    (Unité des Aspergillus, Institut Pasteur)

  • Sophie Paris

    (Unité des Aspergillus, Institut Pasteur)

  • Axel A. Brakhage

    (Leibniz-Institute for Natural Product Research and Infection Biology (HKI) and Friedrich Schiller University)

  • Srini V. Kaveri

    (INSERM, U 872,
    Centre de Recherche des Cordeliers, Université Pierre et Marie Curie–Paris 6, UMR S 872,
    Université Paris Descartes, UMR S 872, Paris F-75006, France)

  • Luigina Romani

    (Department of Experimental Medicine and Biochemical Sciences,)

  • Jean-Paul Latgé

    (Unité des Aspergillus, Institut Pasteur)

Abstract

Breathe easy: why inhaled fungal spores don't provoke an immune reaction Every day we inhale thousands of tiny fungal spores (conidia), originating from many different fungal species. Yet although these spores are packed with antigens and allergens, their inhalation does not continuously activate our innate immune cells or provoke inflammatory responses. A series of immunological, biochemical and genetic experiments shows why: immune recognition of these spores is prevented by a hydrophobic layer of rodlet proteins covering the conidial surface. If this layer is removed, spores activate the immune system. A pathogenic spore equipped with this defensive layer might lie dormant beyond host defences until conditions are suitable for germination. Therapeutically the robust nature of the rodlet proteins might be exploited to generate nanoparticles containing embedded molecules targeted to a specific location in the body, or optimized for sustained delivery.

Suggested Citation

  • Vishukumar Aimanianda & Jagadeesh Bayry & Silvia Bozza & Olaf Kniemeyer & Katia Perruccio & Sri Ramulu Elluru & Cécile Clavaud & Sophie Paris & Axel A. Brakhage & Srini V. Kaveri & Luigina Romani & Je, 2009. "Surface hydrophobin prevents immune recognition of airborne fungal spores," Nature, Nature, vol. 460(7259), pages 1117-1121, August.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7259:d:10.1038_nature08264
    DOI: 10.1038/nature08264
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    Cited by:

    1. Aniket Magarkar & Nawel Mele & Noha Abdel-Rahman & Sarah Butcher & Mika Torkkeli & Ritva Serimaa & Arja Paananen & Markus Linder & Alex Bunker, 2014. "Hydrophobin Film Structure for HFBI and HFBII and Mechanism for Accelerated Film Formation," PLOS Computational Biology, Public Library of Science, vol. 10(7), pages 1-13, July.
    2. Sarah Dellière & Camille Chauvin & Sarah Sze Wah Wong & Markus Gressler & Valentina Possetti & Raffaella Parente & Thierry Fontaine & Thomas Krüger & Olaf Kniemeyer & Jagadeesh Bayry & Agostinho Carva, 2024. "Interplay between host humoral pattern recognition molecules controls undue immune responses against Aspergillus fumigatus," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Zhuozhi Chen & Rongdi Duan & Yunjie Xiao & Yi Wei & Hanxiao Zhang & Xinzhao Sun & Shen Wang & Yingying Cheng & Xue Wang & Shanwei Tong & Yunxiao Yao & Cheng Zhu & Haitao Yang & Yanyan Wang & Zefang Wa, 2022. "Biodegradation of highly crystallized poly(ethylene terephthalate) through cell surface codisplay of bacterial PETase and hydrophobin," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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