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Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex

Author

Listed:
  • Shingo Kajimura

    (Dana-Farber Cancer Institute,
    Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA)

  • Patrick Seale

    (Dana-Farber Cancer Institute,
    Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA)

  • Kazuishi Kubota

    (Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA)

  • Elaine Lunsford

    (Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA)

  • John V. Frangioni

    (Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA)

  • Steven P. Gygi

    (Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA)

  • Bruce M. Spiegelman

    (Dana-Farber Cancer Institute,
    Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA)

Abstract

Brown fat and obesity Brown fat tissue can act to counteract obesity, by burning calories to produce heat, whereas white fat acts as an energy store. Bruce Spiegelman and colleagues reported in Nature last year that brown fat cells are closely related to skeletal muscle, and that the protein PRDM16 can instruct muscle stem cells to become brown fat cells. Now from the same lab comes the finding that PRDM16 works together with C/EBP-β and that expression of this transcriptional unit is sufficient to induce a fully functional brown fat in naive fibroblasts. Transplantation of such fibroblasts into mice creates a brown fat pad that acts as a sink for glucose. This work could lead to new approaches to controlling metabolic disorders such as obesity and type-2 diabetes.

Suggested Citation

  • Shingo Kajimura & Patrick Seale & Kazuishi Kubota & Elaine Lunsford & John V. Frangioni & Steven P. Gygi & Bruce M. Spiegelman, 2009. "Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex," Nature, Nature, vol. 460(7259), pages 1154-1158, August.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7259:d:10.1038_nature08262
    DOI: 10.1038/nature08262
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    Cited by:

    1. Suyang Wu & Chen Qiu & Jiahao Ni & Wenli Guo & Jiyuan Song & Xingyin Yang & Yulin Sun & Yanjun Chen & Yunxia Zhu & Xiaoai Chang & Peng Sun & Chunxia Wang & Kai Li & Xiao Han, 2024. "M2 macrophages independently promote beige adipogenesis via blocking adipocyte Ets1," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Xun Huang & Xinmeng Li & Hongyu Shen & Yiheng Zhao & Zhao Zhou & Yushuang Wang & Jingfei Yao & Kaili Xue & Dongmei Wu & Yifu Qiu, 2023. "Transcriptional repression of beige fat innervation via a YAP/TAZ-S100B axis," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Zimeng Xin & Tianying Zhang & Qinyue Lu & Zhangping Yang & Zhi Chen, 2022. "Progress of m 6 A Methylation in Lipid Metabolism in Humans and Animals," Agriculture, MDPI, vol. 12(10), pages 1-18, October.
    4. Fenfen Li & Jia Jing & Miranda Movahed & Xin Cui & Qiang Cao & Rui Wu & Ziyue Chen & Liqing Yu & Yi Pan & Huidong Shi & Hang Shi & Bingzhong Xue, 2021. "Epigenetic interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown fat," Nature Communications, Nature, vol. 12(1), pages 1-22, December.

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