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Progress of m 6 A Methylation in Lipid Metabolism in Humans and Animals

Author

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  • Zimeng Xin

    (College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China)

  • Tianying Zhang

    (Shaanxi Key Laboratory of Brain Disorders & Institute of Basic and Translational Medicine, Xi’an Medical University, No.1 Xinwang Road, Xi’an 710021, China)

  • Qinyue Lu

    (College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China)

  • Zhangping Yang

    (College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
    Joint International Research Laboratory of Agriculture & Agri-Product Safety, Ministry of Education, Yangzhou University, Yangzhou 225009, China)

  • Zhi Chen

    (College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
    Joint International Research Laboratory of Agriculture & Agri-Product Safety, Ministry of Education, Yangzhou University, Yangzhou 225009, China)

Abstract

N6-methyladenosine (m 6 A) methylation is a type of methylation modification discovered on RNA molecules, mainly on mRNAs, as well as on other RNAs. Similar to DNA methylation, m 6 A methylation regulates the post-transcriptional expression level of genes without altering their base sequences. It modulates gene expression mainly by affecting the binding of mRNAs to reader proteins, thereby regulating variable splicing, translation efficiency, and stability of mRNAs. Early in the research, the study of m 6 A-related biological functions was greatly hindered due to the lack of effective detection methods. As second-generation sequencing and bioinformatics develop, several methods have been available to detect and predict m 6 A methylation sites in recent years. Moreover, m 6 A methylation is also closely related to the development of lipid metabolism, as shown in current studies. Combined with recent research, this paper reviews the concept, detection, and prediction means of m 6 A methylation, especially the relationship between m 6 A and lipid metabolism, providing a new clue to enrich the molecular mechanism of lipid metabolism.

Suggested Citation

  • Zimeng Xin & Tianying Zhang & Qinyue Lu & Zhangping Yang & Zhi Chen, 2022. "Progress of m 6 A Methylation in Lipid Metabolism in Humans and Animals," Agriculture, MDPI, vol. 12(10), pages 1-18, October.
    • Handle: RePEc:gam:jagris:v:12:y:2022:i:10:p:1683-:d:941111
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    References listed on IDEAS

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    1. Shingo Kajimura & Patrick Seale & Kazuishi Kubota & Elaine Lunsford & John V. Frangioni & Steven P. Gygi & Bruce M. Spiegelman, 2009. "Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex," Nature, Nature, vol. 460(7259), pages 1154-1158, August.
    2. Xinzhi Li & Kaixin Ding & Xueying Li & Bingchuan Yuan & Yuqin Wang & Zhicheng Yao & Shuaikang Wang & He Huang & Bolin Xu & Liwei Xie & Tuo Deng & Xiao-wei Chen & Zheng Chen, 2022. "Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH)," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
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    Cited by:

    1. Sitian Yang & Xiang Cao & Yu Wang & Cong Li & Zhi Chen, 2023. "Genetics and Production of Safe, High-Quality Milk by Dairy Cattle," Agriculture, MDPI, vol. 13(7), pages 1-3, July.

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