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L1 retrotransposition in human neural progenitor cells

Author

Listed:
  • Nicole G. Coufal

    (Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • José L. Garcia-Perez

    (1241 East Catherine Street, University of Michigan Medical School, Ann Arbor, Michigan 48109-5618, USA
    Andalusian Stem Cell Bank, Center for Biomedical Research, Avda Conocimiento s/n, University of Granada, 18100, Spain)

  • Grace E. Peng

    (Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Gene W. Yeo

    (Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Present address: Stem Cell Program, Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-5004, USA.)

  • Yangling Mu

    (Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Michael T. Lovci

    (Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Present address: Stem Cell Program, Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-5004, USA.)

  • Maria Morell

    (109 Zina Pitcher, University of Michigan Medical School, Ann Arbor, Michigan 48109-2200, USA)

  • K. Sue O’Shea

    (109 Zina Pitcher, University of Michigan Medical School, Ann Arbor, Michigan 48109-2200, USA)

  • John V. Moran

    (1241 East Catherine Street, University of Michigan Medical School, Ann Arbor, Michigan 48109-5618, USA
    Howard Hughes Medical Institute, Chevy Chase, Maryland 20815-6789, USA)

  • Fred H. Gage

    (Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

Abstract

Shaping the individual brain It is known that LINE-1 (long interspersed element-1) retrotransposons can move throughout the genomes of adult rat neural progenitor cells (NPCs) in vitro and in the mouse brain. Now it is shown that NPCs isolated from human fetal brain and derived from human embryonic stem cells also support the retrotransposition of engineered human LINE-1s in vitro. Interestingly, there is an increase in the copy number of endogenous LINE-1s in the hippocampus and elsewhere in adult human brains when compared to the copy number of endogenous LINE-1s in heart or liver genomic DNA from the same individual. This suggests that LINE-1 retrotransposition events may contribute to individual somatic mosaicism and heterogeneity of gene expression in the brain.

Suggested Citation

  • Nicole G. Coufal & José L. Garcia-Perez & Grace E. Peng & Gene W. Yeo & Yangling Mu & Michael T. Lovci & Maria Morell & K. Sue O’Shea & John V. Moran & Fred H. Gage, 2009. "L1 retrotransposition in human neural progenitor cells," Nature, Nature, vol. 460(7259), pages 1127-1131, August.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7259:d:10.1038_nature08248
    DOI: 10.1038/nature08248
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    Citations

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    Cited by:

    1. Ahmad Luqman-Fatah & Yuzo Watanabe & Kazuko Uno & Fuyuki Ishikawa & John V. Moran & Tomoichiro Miyoshi, 2023. "The interferon stimulated gene-encoded protein HELZ2 inhibits human LINE-1 retrotransposition and LINE-1 RNA-mediated type I interferon induction," Nature Communications, Nature, vol. 14(1), pages 1-26, December.
    2. Sung-Yeon Hwang & Hyewon Kim & Danielle Denisko & Boxun Zhao & Dohoon Lee & Jiseok Jeong & Jinuk Kim & Kiwon Park & Junhyun Park & Dongjoon Jeong & Sehong Park & Hee-Jung Choi & Sun Kim & Eunjung Alic, 2024. "Human cytomegalovirus harnesses host L1 retrotransposon for efficient replication," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Zhengyi Zhen & Yu Chen & Haiyan Wang & Huanyin Tang & Haiping Zhang & Haipeng Liu & Ying Jiang & Zhiyong Mao, 2023. "Nuclear cGAS restricts L1 retrotransposition by promoting TRIM41-mediated ORF2p ubiquitination and degradation," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Chen Sun & Kunal Kathuria & Sarah B. Emery & ByungJun Kim & Ian E. Burbulis & Joo Heon Shin & Daniel R. Weinberger & John V. Moran & Jeffrey M. Kidd & Ryan E. Mills & Michael J. McConnell, 2024. "Mapping recurrent mosaic copy number variation in human neurons," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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