Author
Listed:
- Nicole G. Coufal
(Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)
- José L. Garcia-Perez
(1241 East Catherine Street, University of Michigan Medical School, Ann Arbor, Michigan 48109-5618, USA
Andalusian Stem Cell Bank, Center for Biomedical Research, Avda Conocimiento s/n, University of Granada, 18100, Spain)
- Grace E. Peng
(Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)
- Gene W. Yeo
(Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Present address: Stem Cell Program, Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-5004, USA.)
- Yangling Mu
(Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)
- Michael T. Lovci
(Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Present address: Stem Cell Program, Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-5004, USA.)
- Maria Morell
(109 Zina Pitcher, University of Michigan Medical School, Ann Arbor, Michigan 48109-2200, USA)
- K. Sue O’Shea
(109 Zina Pitcher, University of Michigan Medical School, Ann Arbor, Michigan 48109-2200, USA)
- John V. Moran
(1241 East Catherine Street, University of Michigan Medical School, Ann Arbor, Michigan 48109-5618, USA
Howard Hughes Medical Institute, Chevy Chase, Maryland 20815-6789, USA)
- Fred H. Gage
(Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)
Abstract
Shaping the individual brain It is known that LINE-1 (long interspersed element-1) retrotransposons can move throughout the genomes of adult rat neural progenitor cells (NPCs) in vitro and in the mouse brain. Now it is shown that NPCs isolated from human fetal brain and derived from human embryonic stem cells also support the retrotransposition of engineered human LINE-1s in vitro. Interestingly, there is an increase in the copy number of endogenous LINE-1s in the hippocampus and elsewhere in adult human brains when compared to the copy number of endogenous LINE-1s in heart or liver genomic DNA from the same individual. This suggests that LINE-1 retrotransposition events may contribute to individual somatic mosaicism and heterogeneity of gene expression in the brain.
Suggested Citation
Nicole G. Coufal & José L. Garcia-Perez & Grace E. Peng & Gene W. Yeo & Yangling Mu & Michael T. Lovci & Maria Morell & K. Sue O’Shea & John V. Moran & Fred H. Gage, 2009.
"L1 retrotransposition in human neural progenitor cells,"
Nature, Nature, vol. 460(7259), pages 1127-1131, August.
Handle:
RePEc:nat:nature:v:460:y:2009:i:7259:d:10.1038_nature08248
DOI: 10.1038/nature08248
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Citations
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Cited by:
- Ahmad Luqman-Fatah & Yuzo Watanabe & Kazuko Uno & Fuyuki Ishikawa & John V. Moran & Tomoichiro Miyoshi, 2023.
"The interferon stimulated gene-encoded protein HELZ2 inhibits human LINE-1 retrotransposition and LINE-1 RNA-mediated type I interferon induction,"
Nature Communications, Nature, vol. 14(1), pages 1-26, December.
- Zhengyi Zhen & Yu Chen & Haiyan Wang & Huanyin Tang & Haiping Zhang & Haipeng Liu & Ying Jiang & Zhiyong Mao, 2023.
"Nuclear cGAS restricts L1 retrotransposition by promoting TRIM41-mediated ORF2p ubiquitination and degradation,"
Nature Communications, Nature, vol. 14(1), pages 1-14, December.
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