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EBI2 mediates B cell segregation between the outer and centre follicle

Author

Listed:
  • João P. Pereira

    (University of California San Francisco, California 94143, USA)

  • Lisa M. Kelly

    (University of California San Francisco, California 94143, USA)

  • Ying Xu

    (University of California San Francisco, California 94143, USA)

  • Jason G. Cyster

    (University of California San Francisco, California 94143, USA)

Abstract

B-cell segregation: a role for orphan receptor EB12 The correct positioning of B cells within lymphoid follicles is critical for mounting antibody responses, and positioning of activated B cells in interfollicular regions and in the outer follicle is also thought to be important for supporting normal interactions between T cells and B cells and normal B-cell proliferation. The molecular cues controlling these positioning events have been unknown. Pereira et al. now establish that EBI2, an orphan G-protein-coupled receptor upregulated by Epstein–Barr virus infection, promotes B-cell positioning in the outer follicle. By down-regulating EBI2, germinal centre B cells are able to move to the follicle centre. Mice lacking or mis-expressing this receptor are shown to mount defective antibody responses.

Suggested Citation

  • João P. Pereira & Lisa M. Kelly & Ying Xu & Jason G. Cyster, 2009. "EBI2 mediates B cell segregation between the outer and centre follicle," Nature, Nature, vol. 460(7259), pages 1122-1126, August.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7259:d:10.1038_nature08226
    DOI: 10.1038/nature08226
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    1. Meiling Zheng & Zhi Hu & Xiaole Mei & Lianlian Ouyang & Yang Song & Wenhui Zhou & Yi Kong & Ruifang Wu & Shijia Rao & Hai Long & Wei Shi & Hui Jing & Shuang Lu & Haijing Wu & Sujie Jia & Qianjin Lu & , 2022. "Single-cell sequencing shows cellular heterogeneity of cutaneous lesions in lupus erythematosus," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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