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Partial penetrance facilitates developmental evolution in bacteria

Author

Listed:
  • Avigdor Eldar

    (California Institute of Technology, Pasadena, California 91125, USA)

  • Vasant K. Chary

    (Temple University School of Medicine, 3400 North Broad Street, Philadelphia, Pennsylvania 19140, USA)

  • Panagiotis Xenopoulos

    (Temple University School of Medicine, 3400 North Broad Street, Philadelphia, Pennsylvania 19140, USA)

  • Michelle E. Fontes

    (California Institute of Technology, Pasadena, California 91125, USA)

  • Oliver C. Losón

    (California Institute of Technology, Pasadena, California 91125, USA)

  • Jonathan Dworkin

    (College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA)

  • Patrick J. Piggot

    (Temple University School of Medicine, 3400 North Broad Street, Philadelphia, Pennsylvania 19140, USA)

  • Michael B. Elowitz

    (California Institute of Technology, Pasadena, California 91125, USA)

Abstract

The role of partial penetrance in development Geneticists have long known that individuals with exactly the same genetic make-up can differ from one another in their development and resulting phenotype, but the developmental and evolutionary significance of the phenomenon are not clear. The nature of this 'partial penetrance', whereby the effects of a mutation are observed only in some individuals, even in an isogenic population, has been studied using Bacillus subtilis sporulation as a model developmental system. The results suggest how mutations affecting DNA replication and cell division may act in synergy to facilitate the evolution of twin sporulation as a new trait, through progressive increases in its penetrance.

Suggested Citation

  • Avigdor Eldar & Vasant K. Chary & Panagiotis Xenopoulos & Michelle E. Fontes & Oliver C. Losón & Jonathan Dworkin & Patrick J. Piggot & Michael B. Elowitz, 2009. "Partial penetrance facilitates developmental evolution in bacteria," Nature, Nature, vol. 460(7254), pages 510-514, July.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7254:d:10.1038_nature08150
    DOI: 10.1038/nature08150
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    Cited by:

    1. David M Holloway & Francisco J P Lopes & Luciano da Fontoura Costa & Bruno A N Travençolo & Nina Golyandina & Konstantin Usevich & Alexander V Spirov, 2011. "Gene Expression Noise in Spatial Patterning: hunchback Promoter Structure Affects Noise Amplitude and Distribution in Drosophila Segmentation," PLOS Computational Biology, Public Library of Science, vol. 7(2), pages 1-18, February.

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