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The AP-1 transcription factor Batf controls TH17 differentiation

Author

Listed:
  • Barbara U. Schraml

    (Department of Pathology and Immunology,)

  • Kai Hildner

    (Department of Pathology and Immunology,
    Howard Hughes Medical Institute,)

  • Wataru Ise

    (Department of Pathology and Immunology,
    Howard Hughes Medical Institute,)

  • Wan-Ling Lee

    (Department of Pathology and Immunology,)

  • Whitney A.-E. Smith

    (Department of Pathology and Immunology,)

  • Ben Solomon

    (Department of Pathology and Immunology,)

  • Gurmukh Sahota

    (Department of Genetics,)

  • Julia Sim

    (Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, Missouri 63110, USA)

  • Ryuta Mukasa

    (University of Alabama at Birmingham, University Station, Birmingham, Alabama 35294, USA)

  • Saso Cemerski

    (Department of Pathology and Immunology,)

  • Robin D. Hatton

    (University of Alabama at Birmingham, University Station, Birmingham, Alabama 35294, USA)

  • Gary D. Stormo

    (Department of Genetics,)

  • Casey T. Weaver

    (University of Alabama at Birmingham, University Station, Birmingham, Alabama 35294, USA)

  • John H. Russell

    (Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, Missouri 63110, USA)

  • Theresa L. Murphy

    (Department of Pathology and Immunology,)

  • Kenneth M. Murphy

    (Department of Pathology and Immunology,
    Howard Hughes Medical Institute,)

Abstract

New role for AP-1/JUN AP-1 (activator protein-1) transcription factors, also known as JUN factors, are broadly acting factors regulating many inducible genetic responses. Schraml et al. report a surprising mechanism that expands the biological repertoire of the AP-1 family. They find that the AP-1 transcription factor Batf plays a critical role in the differentiation of IL17-producing T-helper cells.

Suggested Citation

  • Barbara U. Schraml & Kai Hildner & Wataru Ise & Wan-Ling Lee & Whitney A.-E. Smith & Ben Solomon & Gurmukh Sahota & Julia Sim & Ryuta Mukasa & Saso Cemerski & Robin D. Hatton & Gary D. Stormo & Casey , 2009. "The AP-1 transcription factor Batf controls TH17 differentiation," Nature, Nature, vol. 460(7253), pages 405-409, July.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7253:d:10.1038_nature08114
    DOI: 10.1038/nature08114
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    Cited by:

    1. A. Das & G. Ariyakumar & N. Gupta & S. Kamdar & A. Barugahare & D. Deveson-Lucas & S. Gee & K. Costeloe & M. S. Davey & P. Fleming & D. L. Gibbons, 2024. "Identifying immune signatures of sepsis to increase diagnostic accuracy in very preterm babies," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Nicholas L. Dooley & Tinashe G. Chabikwa & Zuleima Pava & Jessica R. Loughland & Julianne Hamelink & Kiana Berry & Dean Andrew & Megan S. F. Soon & Arya SheelaNair & Kim A. Piera & Timothy William & B, 2023. "Single cell transcriptomics shows that malaria promotes unique regulatory responses across multiple immune cell subsets," Nature Communications, Nature, vol. 14(1), pages 1-22, December.

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