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Identifying immune signatures of sepsis to increase diagnostic accuracy in very preterm babies

Author

Listed:
  • A. Das

    (King’s College London, Guy’s Hospital
    University College London)

  • G. Ariyakumar

    (King’s College London, Guy’s Hospital)

  • N. Gupta

    (Evelina London Neonatal Unit, Guy’s and St Thomas’ NHS Foundation Trust
    King’s College London)

  • S. Kamdar

    (King’s College London, Guy’s Hospital)

  • A. Barugahare

    (Monash University)

  • D. Deveson-Lucas

    (Monash University)

  • S. Gee

    (King’s College London, Guy’s Hospital)

  • K. Costeloe

    (Queen Mary University of London)

  • M. S. Davey

    (Monash University
    University of Warwick)

  • P. Fleming

    (Queen Mary University of London
    Homerton Healthcare NHS Foundation Trust)

  • D. L. Gibbons

    (King’s College London, Guy’s Hospital)

Abstract

Bacterial infections are a major cause of mortality in preterm babies, yet our understanding of early-life disease-associated immune dysregulation remains limited. Here, we combine multi-parameter flow cytometry, single-cell RNA sequencing and plasma analysis to longitudinally profile blood from very preterm babies (

Suggested Citation

  • A. Das & G. Ariyakumar & N. Gupta & S. Kamdar & A. Barugahare & D. Deveson-Lucas & S. Gee & K. Costeloe & M. S. Davey & P. Fleming & D. L. Gibbons, 2024. "Identifying immune signatures of sepsis to increase diagnostic accuracy in very preterm babies," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-44387-5
    DOI: 10.1038/s41467-023-44387-5
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    References listed on IDEAS

    as
    1. Barbara U. Schraml & Kai Hildner & Wataru Ise & Wan-Ling Lee & Whitney A.-E. Smith & Ben Solomon & Gurmukh Sahota & Julia Sim & Ryuta Mukasa & Saso Cemerski & Robin D. Hatton & Gary D. Stormo & Casey , 2009. "The AP-1 transcription factor Batf controls TH17 differentiation," Nature, Nature, vol. 460(7253), pages 405-409, July.
    2. Claire L. Smith & Paul Dickinson & Thorsten Forster & Marie Craigon & Alan Ross & Mizanur R. Khondoker & Rebecca France & Alasdair Ivens & David J. Lynn & Judith Orme & Allan Jackson & Paul Lacaze & K, 2014. "Identification of a human neonatal immune-metabolic network associated with bacterial infection," Nature Communications, Nature, vol. 5(1), pages 1-15, December.
    Full references (including those not matched with items on IDEAS)

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