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A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells

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  • Hitoshi Niwa

    (Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe 6500047, Japan
    Laboratory for Development and Regenerative Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunokicho, Chuo-ku, Kobe 6500017, Japan
    JST, CREST, Sanbancho, Chiyoda-ku, Tokyo, 1020075, Japan)

  • Kazuya Ogawa

    (Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe 6500047, Japan)

  • Daisuke Shimosato

    (Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe 6500047, Japan
    Laboratory for Development and Regenerative Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunokicho, Chuo-ku, Kobe 6500017, Japan)

  • Kenjiro Adachi

    (Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe 6500047, Japan)

Abstract

Pluripotency factors dissected The cytokine leukaemia inhibitory factor (LIF) integrates signals into mouse embryonic stem cells to maintain pluripotency. The Jak-Stat3 pathway is known to mediate LIF signals, but it is not clear how these signals are linked to the core circuitry of pluripotency-associated transcription factors: Oct3/4, Sox2 and Nanog. Here Niwa et al. show that two LIF signalling pathways are each connected to the core circuitry by different transcription factors, thus there are parallel pathways controlling pluripotency. This paper is notable in that it is the one of the first, if not the first, to report a dissection of the functional hierarchy of transcription factors that maintains self-renewal of mouse embryonic stem cells.

Suggested Citation

  • Hitoshi Niwa & Kazuya Ogawa & Daisuke Shimosato & Kenjiro Adachi, 2009. "A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells," Nature, Nature, vol. 460(7251), pages 118-122, July.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7251:d:10.1038_nature08113
    DOI: 10.1038/nature08113
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    Cited by:

    1. Dasol Han & Guojing Liu & Yujeong Oh & Seyoun Oh & Seungbok Yang & Lori Mandjikian & Neha Rani & Maria C. Almeida & Kenneth S. Kosik & Jiwon Jang, 2023. "ZBTB12 is a molecular barrier to dedifferentiation in human pluripotent stem cells," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Chen Dong & Shuhua Fu & Rowan M. Karvas & Brian Chew & Laura A. Fischer & Xiaoyun Xing & Jessica K. Harrison & Pooja Popli & Ramakrishna Kommagani & Ting Wang & Bo Zhang & Thorold W. Theunissen, 2022. "A genome-wide CRISPR-Cas9 knockout screen identifies essential and growth-restricting genes in human trophoblast stem cells," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Haipeng Fu & Tingyu Wang & Xiaohui Kong & Kun Yan & Yang Yang & Jingyi Cao & Yafei Yuan & Nan Wang & Kehkooi Kee & Zhi John Lu & Qiaoran Xi, 2022. "A Nodal enhanced micropeptide NEMEP regulates glucose uptake during mesendoderm differentiation of embryonic stem cells," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    4. David Yeo & Alexandros Kiparissides & Jae Min Cha & Cristobal Aguilar-Gallardo & Julia M Polak & Elefterios Tsiridis & Efstratios N Pistikopoulos & Athanasios Mantalaris, 2013. "Improving Embryonic Stem Cell Expansion through the Combination of Perfusion and Bioprocess Model Design," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-14, December.
    5. Vincenzo Paduano & Daniela Tagliaferri & Geppino Falco & Michele Ceccarelli, 2013. "Automated Identification and Location Analysis of Marked Stem Cells Colonies in Optical Microscopy Images," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-11, December.

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