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A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

Author

Listed:
  • Philipp Niethammer

    (Harvard Medical School, Boston)

  • Clemens Grabher

    (Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Present address: Karlsruhe Institute of Technology, Forschungszentrum Karlsruhe GmbH, Institute of Toxicology and Genetics, 76344 Eggenstein-Leopoldshafen, Germany.)

  • A. Thomas Look

    (Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Children’s Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA)

  • Timothy J. Mitchison

    (Harvard Medical School, Boston)

Abstract

Hydrogen peroxide role in wound detection A study of the role of hydrogen peroxide (H2O2) during the early events of wound responses in zebrafish larvae — a popular vertebrate model for inflammatory and regenerative responses to wounds — reveals a that tissue gradient of H2O2 forms in response to injury of the zebrafish tail fin. The gradient, made visible by the use of a genetically encoded fluorescent sensor protein, is created by the activity of dual oxidase (DUOX) and acts to attract leukocytes to the wound margin during the initial phase of inflammation. This is the first report of a role for H2O2 in signalling to leukocytes, in addition to its established role as an antiseptic.

Suggested Citation

  • Philipp Niethammer & Clemens Grabher & A. Thomas Look & Timothy J. Mitchison, 2009. "A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish," Nature, Nature, vol. 459(7249), pages 996-999, June.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7249:d:10.1038_nature08119
    DOI: 10.1038/nature08119
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    Cited by:

    1. Francisco J Martínez-Morcillo & Joaquín Cantón-Sandoval & Francisco J Martínez-Navarro & Isabel Cabas & Idoya Martínez-Vicente & Joy Armistead & Julia Hatzold & Azucena López-Muñoz & Teresa Martínez-M, 2021. "NAMPT-derived NAD+ fuels PARP1 to promote skin inflammation through parthanatos cell death," PLOS Biology, Public Library of Science, vol. 19(11), pages 1-27, November.
    2. Elizabeth Jose & Woody March-Steinman & Bryce A. Wilson & Lisa Shanks & Chance Parkinson & Isabel Alvarado-Cruz & Joann B. Sweasy & Andrew L. Paek, 2024. "Temporal coordination of the transcription factor response to H2O2 stress," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Andrea Pessina & Mariangela Di Vincenzo & Francesca Maradonna & Francesca Marchegiani & Fabiola Olivieri & Basilio Randazzo & Giorgia Gioacchini & Oliana Carnevali, 2021. "Polydatin Beneficial Effects in Zebrafish Larvae Undergoing Multiple Stress Types," IJERPH, MDPI, vol. 18(3), pages 1-13, January.
    4. Alvin Eng Kiat Loo & Yee Ting Wong & Rongjian Ho & Martin Wasser & Tiehua Du & Wee Thong Ng & Barry Halliwell, 2012. "Effects of Hydrogen Peroxide on Wound Healing in Mice in Relation to Oxidative Damage," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-13, November.

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