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Polydatin Beneficial Effects in Zebrafish Larvae Undergoing Multiple Stress Types

Author

Listed:
  • Andrea Pessina

    (Department of Life and Environmental Sciences, DiSVA, Università Politecnica delle Marche, 60131 Ancona, Italy
    These authors equally contributed to the manuscript.)

  • Mariangela Di Vincenzo

    (Department of Life and Environmental Sciences, DiSVA, Università Politecnica delle Marche, 60131 Ancona, Italy
    These authors equally contributed to the manuscript.)

  • Francesca Maradonna

    (Department of Life and Environmental Sciences, DiSVA, Università Politecnica delle Marche, 60131 Ancona, Italy)

  • Francesca Marchegiani

    (Center of Clinical Pathology and Innovative Therapy, IRCCS INRCA, 60100 Ancona, Italy)

  • Fabiola Olivieri

    (Center of Clinical Pathology and Innovative Therapy, IRCCS INRCA, 60100 Ancona, Italy
    Department of Clinical and Molecular Sciences, DISCLIMO, Università Politecnica delle Marche, 60100 Ancona, Italy)

  • Basilio Randazzo

    (Department of Life and Environmental Sciences, DiSVA, Università Politecnica delle Marche, 60131 Ancona, Italy)

  • Giorgia Gioacchini

    (Department of Life and Environmental Sciences, DiSVA, Università Politecnica delle Marche, 60131 Ancona, Italy)

  • Oliana Carnevali

    (Department of Life and Environmental Sciences, DiSVA, Università Politecnica delle Marche, 60131 Ancona, Italy)

Abstract

Polydatin is a polyphenol, whose beneficial properties, including anti-inflammatory and antioxidant activity, have been largely demonstrated. At the same time, copper has an important role in the correct organism homeostasis and alteration of its concentration can induce oxidative stress. In this study, the efficacy of polydatin to counteract the stress induced by CuSO 4 exposure or by caudal fin amputation was investigated in zebrafish larvae. The study revealed that polydatin can reduced the stress induced by a 2 h exposure to 10 µM CuSO 4 by lowering the levels of il1b and cxcl8b.1 and reducing neutrophils migration in the head and along the lateral line. Similarly, polydatin administration reduced the number of neutrophils in the area of fin cut. In addition, polydatin upregulates the expression of sod1 mRNA and CAT activity, both involved in the antioxidant response. Most of the results obtained in this study support the working hypothesis that polydatin administration can modulate stress response and its action is more effective in mitigating the effects rather than in preventing chemical damages.

Suggested Citation

  • Andrea Pessina & Mariangela Di Vincenzo & Francesca Maradonna & Francesca Marchegiani & Fabiola Olivieri & Basilio Randazzo & Giorgia Gioacchini & Oliana Carnevali, 2021. "Polydatin Beneficial Effects in Zebrafish Larvae Undergoing Multiple Stress Types," IJERPH, MDPI, vol. 18(3), pages 1-13, January.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:3:p:1116-:d:488000
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    References listed on IDEAS

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    1. Philipp Niethammer & Clemens Grabher & A. Thomas Look & Timothy J. Mitchison, 2009. "A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish," Nature, Nature, vol. 459(7249), pages 996-999, June.
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