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Genes that mediate breast cancer metastasis to the brain

Author

Listed:
  • Paula D. Bos

    (Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA)

  • Xiang H.-F. Zhang

    (Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA)

  • Cristina Nadal

    (Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Present addresses: Institut de Malalties Hemato-Oncològiques, Hospital Clínic, 08036 Barcelona, Spain (C.N.); Oncology Programme, Institute for Research in Biomedicine, 08028 Barcelona, Spain (R.R.G.).)

  • Weiping Shu

    (Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA)

  • Roger R. Gomis

    (Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Present addresses: Institut de Malalties Hemato-Oncològiques, Hospital Clínic, 08036 Barcelona, Spain (C.N.); Oncology Programme, Institute for Research in Biomedicine, 08028 Barcelona, Spain (R.R.G.).)

  • Don X. Nguyen

    (Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA)

  • Andy J. Minn

    (and Ludwig Center for Metastasis Research, The University of Chicago, Chicago, Illinois 60637, USA)

  • Marc J. van de Vijver

    (Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands)

  • William L. Gerald

    (Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA)

  • John A. Foekens

    (Erasmus MC Rotterdam, Josephine Nefkens Institute and Cancer Genomics Centre)

  • Joan Massagué

    (Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Howard Hughes Medical Institute, Chevy Chase, Maryland 20185, USA)

Abstract

Brain metastasis in breast cancer Little is known about the mechanisms by which breast cancer cells metastasize to the brain. Bos et al. now identify three genes that are involved in this process. COX2 and HBEGF have previously been shown to also mediate breast cancer metastasis to the lung, suggesting common biological processes that regulate dissemination to these two organs. In addition, they find that ST6GALNAC5 is specifically involved in brain metastasis, by increasing the adhesion of breast cancer cells to the brain endothelium and migration through the blood–brain barrier.

Suggested Citation

  • Paula D. Bos & Xiang H.-F. Zhang & Cristina Nadal & Weiping Shu & Roger R. Gomis & Don X. Nguyen & Andy J. Minn & Marc J. van de Vijver & William L. Gerald & John A. Foekens & Joan Massagué, 2009. "Genes that mediate breast cancer metastasis to the brain," Nature, Nature, vol. 459(7249), pages 1005-1009, June.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7249:d:10.1038_nature08021
    DOI: 10.1038/nature08021
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    Cited by:

    1. Wonbin Park & Jae-Seong Lee & Ge Gao & Byoung Soo Kim & Dong-Woo Cho, 2023. "3D bioprinted multilayered cerebrovascular conduits to study cancer extravasation mechanism related with vascular geometry," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Weili Ma & Maria Cecília Oliveira-Nunes & Ke Xu & Andrew Kossenkov & Benjamin C. Reiner & Richard C. Crist & James Hayden & Qing Chen, 2023. "Type I interferon response in astrocytes promotes brain metastasis by enhancing monocytic myeloid cell recruitment," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Bieke Decaesteker & Amber Louwagie & Siebe Loontiens & Fanny De Vloed & Sarah-Lee Bekaert & Juliette Roels & Suzanne Vanhauwaert & Sara De Brouwer & Ellen Sanders & Alla Berezovskaya & Geertrui Deneck, 2023. "SOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    4. Shen Zhao & Wu Zhuang & Baohui Han & Zhengbo Song & Wei Guo & Feng Luo & Lin Wu & Yi Hu & Huijuan Wang & Xiaorong Dong & Da Jiang & Mingxia Wang & Liyun Miao & Qian Wang & Junping Zhang & Zhenming Fu , 2023. "Phase 1b trial of anti-EGFR antibody JMT101 and Osimertinib in EGFR exon 20 insertion-positive non-small-cell lung cancer," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    5. Johannes Helm & Stefan Mereiter & Tiago Oliveira & Anna Gattinger & David M. Markovitz & Josef M. Penninger & Friedrich Altmann & Johannes Stadlmann, 2024. "Non-targeted N-glycome profiling reveals multiple layers of organ-specific diversity in mice," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    6. Nicola Cosgrove & Damir Varešlija & Stephen Keelan & Ashuvinee Elangovan & Jennifer M. Atkinson & Sinéad Cocchiglia & Fiona T. Bane & Vikrant Singh & Simon Furney & Chunling Hu & Jodi M. Carter & Stev, 2022. "Mapping molecular subtype specific alterations in breast cancer brain metastases identifies clinically relevant vulnerabilities," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    7. Bo Jiang & Xiaozhi Zhao & Wei Chen & Wenli Diao & Meng Ding & Haixiang Qin & Binghua Li & Wenmin Cao & Wei Chen & Yao Fu & Kuiqiang He & Jie Gao & Mengxia Chen & Tingsheng Lin & Yongming Deng & Chao Y, 2022. "Lysosomal protein transmembrane 5 promotes lung-specific metastasis by regulating BMPR1A lysosomal degradation," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    8. Jenniffer Linares & Anna Sallent-Aragay & Jordi Badia-Ramentol & Alba Recort-Bascuas & Ana Méndez & Noemí Manero-Rupérez & Daniele Lo Re & Elisa I. Rivas & Marc Guiu & Melissa Zwick & Mar Iglesias & C, 2023. "Long-term platinum-based drug accumulation in cancer-associated fibroblasts promotes colorectal cancer progression and resistance to therapy," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    9. Ke Li & Jiawei Guo & Yue Ming & Shuang Chen & Tingting Zhang & Hulin Ma & Xin Fu & Jin Wang & Wenrong Liu & Yong Peng, 2023. "A circular RNA activated by TGFβ promotes tumor metastasis through enhancing IGF2BP3-mediated PDPN mRNA stability," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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