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Unlocking the secrets of the genome

Author

Listed:
  • Susan E. Celniker

    (Lawrence Berkeley National Laboratory)

  • Laura A. L. Dillon

    (National Human Genome Research Institute, National Institutes of Health)

  • Mark B. Gerstein

    (Program in Computational Biology and Bioinformatics, Yale University
    Yale University)

  • Kristin C. Gunsalus

    (Center for Genomics and Systems Biology, New York University)

  • Steven Henikoff

    (Fred Hutchinson Cancer Research Center)

  • Gary H. Karpen

    (Lawrence Berkeley National Laboratory, University of California)

  • Manolis Kellis

    (Broad Institute, Massachusetts Institute of Technology and Harvard University
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology)

  • Eric C. Lai

    (Sloan-Kettering Institute)

  • Jason D. Lieb

    (University of North Carolina at Chapel Hill)

  • David M. MacAlpine

    (Duke University Medical Center)

  • Gos Micklem

    (University of Cambridge, CB2 3EH, UK, and Cambridge Systems Biology Centre, Tennis Court Road)

  • Fabio Piano

    (Center for Genomics and Systems Biology, New York University)

  • Michael Snyder

    (Cellular and Developmental Biology, Yale University)

  • Lincoln Stein

    (Cold Spring Harbor Laboratory, Cold Spring Harbor)

  • Kevin P. White

    (Institute for Genomics & Systems Biology, University of Chicago
    Institute for Genomics & Systems Biology, Argonne National Laboratory)

  • Robert H. Waterston

    (Department of Genome Sciences and University of Washington School of Medicine)

Abstract

Despite the successes of genomics, little is known about how genetic information produces complex organisms. A look at the crucial functional elements of fly and worm genomes could change that.

Suggested Citation

  • Susan E. Celniker & Laura A. L. Dillon & Mark B. Gerstein & Kristin C. Gunsalus & Steven Henikoff & Gary H. Karpen & Manolis Kellis & Eric C. Lai & Jason D. Lieb & David M. MacAlpine & Gos Micklem & F, 2009. "Unlocking the secrets of the genome," Nature, Nature, vol. 459(7249), pages 927-930, June.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7249:d:10.1038_459927a
    DOI: 10.1038/459927a
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    Cited by:

    1. Sammy Villa & Pankaj Dwivedi & Aaron Stahl & Trent Hinkle & Christopher M. Rose & Donald S. Kirkpatrick & Seth M. Tomchik & Vishva M. Dixit & Fred W. Wolf, 2024. "OTUD6 deubiquitination of RPS7/eS7 on the free 40 S ribosome regulates global protein translation and stress," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Dafne Ibarra-Morales & Michael Rauer & Piergiuseppe Quarato & Leily Rabbani & Fides Zenk & Mariana Schulte-Sasse & Francesco Cardamone & Alejandro Gomez-Auli & Germano Cecere & Nicola Iovino, 2021. "Histone variant H2A.Z regulates zygotic genome activation," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    3. Dahong Chen & Catherine E. McManus & Behram Radmanesh & Leah H. Matzat & Elissa P. Lei, 2021. "Temporal inhibition of chromatin looping and enhancer accessibility during neuronal remodeling," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    4. Jingting Xu & Hong Hu & Yang Dai, 2016. "LMethyR-SVM: Predict Human Enhancers Using Low Methylated Regions based on Weighted Support Vector Machines," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-18, September.
    5. Yayoi Natsume-Kitatani & Hiroshi Mamitsuka, 2016. "Classification of Promoters Based on the Combination of Core Promoter Elements Exhibits Different Histone Modification Patterns," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-18, March.
    6. Hao Wu & Hongkai Ji, 2014. "PolyaPeak: Detecting Transcription Factor Binding Sites from ChIP-seq Using Peak Shape Information," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-9, March.
    7. Xinhao Hou & Mingjing Xu & Chengming Zhu & Jianing Gao & Meili Li & Xiangyang Chen & Cheng Sun & Björn Nashan & Jianye Zang & Ying Zhou & Shouhong Guang & Xuezhu Feng, 2023. "Systematic characterization of chromodomain proteins reveals an H3K9me1/2 reader regulating aging in C. elegans," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    8. Shijia Zhu & Guohua Wang & Bo Liu & Yadong Wang, 2013. "Modeling Exon Expression Using Histone Modifications," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-15, June.

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