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Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger

Author

Listed:
  • Gang G. Wang

    (Laboratory of Chromatin Biology & Epigenetics, The Rockefeller University, New York, New York 10065, USA)

  • Jikui Song

    (Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA)

  • Zhanxin Wang

    (Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA)

  • Holger L. Dormann

    (Laboratory of Chromatin Biology & Epigenetics, The Rockefeller University, New York, New York 10065, USA)

  • Fabio Casadio

    (Laboratory of Chromatin Biology & Epigenetics, The Rockefeller University, New York, New York 10065, USA)

  • Haitao Li

    (Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA)

  • Jun-Li Luo

    (The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458, USA)

  • Dinshaw J. Patel

    (Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA)

  • C. David Allis

    (Laboratory of Chromatin Biology & Epigenetics, The Rockefeller University, New York, New York 10065, USA)

Abstract

Histones and leukaemia A chromosomal translocation found in certain acute myeloid leukaemia (AML) patients results in fusion of the PHD finger of a chromatin-binding protein to a nucleoporin NUP98. One such fusion protein is now reported to be a potent oncoprotein inducing AML. Introducing mutations in the PHD finger that abrogate its binding to histone H3 trimethylated at Lys4 is shown to abolish tumorigenesis. By binding chromatin, the NUP98-PHD fusion seems to lock developmentally important genes into an active state. Deregulation of an 'effector' of histone modifications can therefore lead to oncogenesis.

Suggested Citation

  • Gang G. Wang & Jikui Song & Zhanxin Wang & Holger L. Dormann & Fabio Casadio & Haitao Li & Jun-Li Luo & Dinshaw J. Patel & C. David Allis, 2009. "Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger," Nature, Nature, vol. 459(7248), pages 847-851, June.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7248:d:10.1038_nature08036
    DOI: 10.1038/nature08036
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    Cited by:

    1. Caojie Liu & Qiuchan Xiong & Qiwen Li & Weimin Lin & Shuang Jiang & Danting Zhang & Yuan Wang & Xiaobo Duan & Ping Gong & Ning Kang, 2022. "CHD7 regulates bone-fat balance by suppressing PPAR-γ signaling," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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