IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v459y2009i7246d10.1038_nature07952.html
   My bibliography  Save this article

Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment

Author

Listed:
  • Minsoo Kim

    (International Research Center for Infectious Diseases
    CREST, Japan Science and Technology Agency)

  • Michinaga Ogawa

    (Institute of Medical Science, University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
    CREST, Japan Science and Technology Agency)

  • Yukihiro Fujita

    (Institute of Medical Science, University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
    CREST, Japan Science and Technology Agency)

  • Yuko Yoshikawa

    (Institute of Medical Science, University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
    CREST, Japan Science and Technology Agency)

  • Takeshi Nagai

    (Institute of Medical Science, University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
    CREST, Japan Science and Technology Agency)

  • Tomohiro Koyama

    (Nippon Institute for Biological Science, 9-2221-1, Shinmachi, Ome, Tokyo 198-0024, Japan)

  • Shinya Nagai

    (Nippon Institute for Biological Science, 9-2221-1, Shinmachi, Ome, Tokyo 198-0024, Japan)

  • Anika Lange

    (Max-Planck Institute of Biochemistry, D-82152, Martinsried, Germany)

  • Reinhard Fässler

    (Max-Planck Institute of Biochemistry, D-82152, Martinsried, Germany)

  • Chihiro Sasakawa

    (International Research Center for Infectious Diseases
    Institute of Medical Science, University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
    CREST, Japan Science and Technology Agency)

Abstract

Bacterial hijack The intestinal epithelium undergoes rapid self-renewal and exfoliation from the basement membrane upon bacterial infection, a process that acts as a defence system against the pathogen. Despite this, many enteropathogenic bacteria can colonize the intestinal epithelium. Now a mechanism enabling pathogens to overcome this form of host defence has been identified. The Shigella virulence factor OspE — also found in many other enteropathogenic bacteria — reinforces host-cell-matrix adherence by interacting with integrin-linked kinase. This may suppress epithelial detachment and promote bacterial colonization within the intestinal epithelium. This suggests that small molecules that block OspE's hijack of integrin-linked kinase may be effective against some intestinal bacterial infections.

Suggested Citation

  • Minsoo Kim & Michinaga Ogawa & Yukihiro Fujita & Yuko Yoshikawa & Takeshi Nagai & Tomohiro Koyama & Shinya Nagai & Anika Lange & Reinhard Fässler & Chihiro Sasakawa, 2009. "Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment," Nature, Nature, vol. 459(7246), pages 578-582, May.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7246:d:10.1038_nature07952
    DOI: 10.1038/nature07952
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature07952
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature07952?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Huilong Luo & Yanmei Chen & Xiao Kuang & Xinyue Wang & Fengmin Yang & Zhenping Cao & Lu Wang & Sisi Lin & Feng Wu & Jinyao Liu, 2022. "Chemical reaction-mediated covalent localization of bacteria," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Yesheng Fu & Lei Li & Xin Zhang & Zhikang Deng & Ying Wu & Wenzhe Chen & Yuchen Liu & Shan He & Jian Wang & Yuping Xie & Zhiwei Tu & Yadi Lyu & Yange Wei & Shujie Wang & Chun-Ping Cui & Cui Hua Liu & , 2024. "Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:459:y:2009:i:7246:d:10.1038_nature07952. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.