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The structure and function of G-protein-coupled receptors

Author

Listed:
  • Daniel M. Rosenbaum

    (Stanford University School of Medicine)

  • Søren G. F. Rasmussen

    (Stanford University School of Medicine)

  • Brian K. Kobilka

    (Stanford University School of Medicine)

Abstract

G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great potential as therapeutic targets for a broad spectrum of diseases. They are also fascinating molecules from the perspective of membrane-protein structure and biology. Great progress has been made over the past three decades in understanding diverse GPCRs, from pharmacology to functional characterization in vivo. Recent high-resolution structural studies have provided insights into the molecular mechanisms of GPCR activation and constitutive activity.

Suggested Citation

  • Daniel M. Rosenbaum & Søren G. F. Rasmussen & Brian K. Kobilka, 2009. "The structure and function of G-protein-coupled receptors," Nature, Nature, vol. 459(7245), pages 356-363, May.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7245:d:10.1038_nature08144
    DOI: 10.1038/nature08144
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    1. Oliver Tejero & Filip Pamula & Mitsumasa Koyanagi & Takashi Nagata & Pavel Afanasyev & Ishita Das & Xavier Deupi & Mordechai Sheves & Akihisa Terakita & Gebhard F. X. Schertler & Matthew J. Rodrigues , 2024. "Active state structures of a bistable visual opsin bound to G proteins," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Wenli Zhao & Wenru Zhang & Mu Wang & Minmin Lu & Shutian Chen & Tingting Tang & Gisela Schnapp & Holger Wagner & Albert Brennauer & Cuiying Yi & Xiaojing Chu & Shuo Han & Beili Wu & Qiang Zhao, 2022. "Ligand recognition and activation of neuromedin U receptor 2," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    3. Mark J. Wall & Emily Hill & Robert Huckstepp & Kerry Barkan & Giuseppe Deganutti & Michele Leuenberger & Barbara Preti & Ian Winfield & Sabrina Carvalho & Anna Suchankova & Haifeng Wei & Dewi Safitri , 2022. "Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    4. Marie Mi Bonde & Jonas Tind Hansen & Samra Joke Sanni & Stig Haunsø & Steen Gammeltoft & Christina Lyngsø & Jakob Lerche Hansen, 2010. "Biased Signaling of the Angiotensin II Type 1 Receptor Can Be Mediated through Distinct Mechanisms," PLOS ONE, Public Library of Science, vol. 5(11), pages 1-15, November.
    5. Eyal Rozenfeld & Merav Tauber & Yair Ben-Chaim & Moshe Parnas, 2021. "GPCR voltage dependence controls neuronal plasticity and behavior," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    6. Arunkumar Krishnan & Markus Sällman Almén & Robert Fredriksson & Helgi B Schiöth, 2012. "The Origin of GPCRs: Identification of Mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in Fungi," PLOS ONE, Public Library of Science, vol. 7(1), pages 1-15, January.
    7. Sathvik Anantakrishnan & Athi N. Naganathan, 2023. "Thermodynamic architecture and conformational plasticity of GPCRs," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    8. Kaihua Zhang & Hao Wu & Nicholas Hoppe & Aashish Manglik & Yifan Cheng, 2022. "Fusion protein strategies for cryo-EM study of G protein-coupled receptors," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    9. Manel Zeghal & Geneviève Laroche & Julia Douglas Freitas & Rebecca Wang & Patrick M. Giguère, 2023. "Profiling of basal and ligand-dependent GPCR activities by means of a polyvalent cell-based high-throughput platform," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    10. Pingfen Zhu & Weiqiang Liu & Xiaoxiao Zhang & Meng Li & Gaoming Liu & Yang Yu & Zihao Li & Xuanjing Li & Juan Du & Xiao Wang & Cyril C. Grueter & Ming Li & Xuming Zhou, 2023. "Correlated evolution of social organization and lifespan in mammals," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    11. Miguel Fribourg & Diomedes E Logothetis & Javier González-Maeso & Stuart C Sealfon & Belén Galocha-Iragüen & Fernando Las-Heras Andrés & Vladimir Brezina, 2017. "Elucidation of molecular kinetic schemes from macroscopic traces using system identification," PLOS Computational Biology, Public Library of Science, vol. 13(2), pages 1-34, February.
    12. Anna Strunecka & Otakar Strunecky, 2019. "Chronic Fluoride Exposure and the Risk of Autism Spectrum Disorder," IJERPH, MDPI, vol. 16(18), pages 1-21, September.

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