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Self-assembly of a nanoscale DNA box with a controllable lid

Author

Listed:
  • Ebbe S. Andersen

    (Danish National Research Foundation: Centre for DNA Nanotechnology,
    Interdisciplinary Nanoscience Center,
    Department of Molecular Biology,)

  • Mingdong Dong

    (Danish National Research Foundation: Centre for DNA Nanotechnology,
    Interdisciplinary Nanoscience Center,
    Department of Physics and Astronomy,
    Present address: Rowland Institute at Harvard, Harvard University, 100 Edwin H. Land Boulevard, Cambridge, Massachusetts 02142, USA.)

  • Morten M. Nielsen

    (Danish National Research Foundation: Centre for DNA Nanotechnology,
    Interdisciplinary Nanoscience Center,
    Department of Molecular Biology,)

  • Kasper Jahn

    (Danish National Research Foundation: Centre for DNA Nanotechnology,
    Interdisciplinary Nanoscience Center,
    Department of Molecular Biology,)

  • Ramesh Subramani

    (Danish National Research Foundation: Centre for DNA Nanotechnology,
    Interdisciplinary Nanoscience Center,
    Department of Physics and Astronomy,)

  • Wael Mamdouh

    (Danish National Research Foundation: Centre for DNA Nanotechnology,
    Interdisciplinary Nanoscience Center,
    Department of Physics and Astronomy,)

  • Monika M. Golas

    (The Water and Salt Research Center, Institute of Anatomy,
    Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D-37077 Göttingen, Germany)

  • Bjoern Sander

    (Stereology and EM Research Laboratory,
    Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D-37077 Göttingen, Germany)

  • Holger Stark

    (Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D-37077 Göttingen, Germany
    Göttingen Centre for Molecular Biology, Justus-von-Liebig-Weg 11, University of Göttingen)

  • Cristiano L. P. Oliveira

    (Interdisciplinary Nanoscience Center,
    Aarhus University, DK-8000 Aarhus, Denmark)

  • Jan Skov Pedersen

    (Interdisciplinary Nanoscience Center,
    Aarhus University, DK-8000 Aarhus, Denmark)

  • Victoria Birkedal

    (Interdisciplinary Nanoscience Center,)

  • Flemming Besenbacher

    (Danish National Research Foundation: Centre for DNA Nanotechnology,
    Interdisciplinary Nanoscience Center,
    Department of Physics and Astronomy,)

  • Kurt V. Gothelf

    (Danish National Research Foundation: Centre for DNA Nanotechnology,
    Interdisciplinary Nanoscience Center,
    Aarhus University, DK-8000 Aarhus, Denmark)

  • Jørgen Kjems

    (Danish National Research Foundation: Centre for DNA Nanotechnology,
    Interdisciplinary Nanoscience Center,
    Department of Molecular Biology,)

Abstract

DNA: boxing clever The use of DNA for the self-assembly of nanostructures has promising applications in chemistry, molecular computing and other emerging areas of nanotechnology. One approach that has shown particular promise is known as 'DNA origami'. Developed by Paul Rothemund, it involves a long single-stranded viral DNA sequence that is folded, with the help of short synthetic oligonucleotides, to create a planar nanostructure of arbitrary shape. Andersen et al. have now extended the DNA origami method into a third dimension by creating an addressable DNA box of 42×36×36 nm3 that can be opened in the presence of an externally supplied 'key'. Controlled access to the interior compartment of this DNA nanocontainer could yield several interesting applications, for example as a logic sensor for multiple-sequence signals or for the controlled release of nanocargos.

Suggested Citation

  • Ebbe S. Andersen & Mingdong Dong & Morten M. Nielsen & Kasper Jahn & Ramesh Subramani & Wael Mamdouh & Monika M. Golas & Bjoern Sander & Holger Stark & Cristiano L. P. Oliveira & Jan Skov Pedersen & V, 2009. "Self-assembly of a nanoscale DNA box with a controllable lid," Nature, Nature, vol. 459(7243), pages 73-76, May.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7243:d:10.1038_nature07971
    DOI: 10.1038/nature07971
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    Citations

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    Cited by:

    1. Shekaari, Ashkan & Jafari, Mahmoud, 2019. "Statistical mechanical modeling of a DNA nanobiostructure at the base-pair level," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 518(C), pages 80-88.
    2. Jeroen F. Dyck & Jonathan R. Burns & Kyle I. P. Huray & Albert Konijnenberg & Stefan Howorka & Frank Sobott, 2022. "Sizing up DNA nanostructure assembly with native mass spectrometry and ion mobility," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    3. Katya Ahmad & Abid Javed & Conor Lanphere & Peter V. Coveney & Elena V. Orlova & Stefan Howorka, 2023. "Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Tomoya Maruyama & Jing Gong & Masahiro Takinoue, 2024. "Temporally controlled multistep division of DNA droplets for dynamic artificial cells," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    5. Muhammad Yaseen & Muhammad Humayun & Abbas Khan & Muhammad Usman & Habib Ullah & Asif Ali Tahir & Habib Ullah, 2021. "Preparation, Functionalization, Modification, and Applications of Nanostructured Gold: A Critical Review," Energies, MDPI, vol. 14(5), pages 1-88, February.
    6. Swarup Dey & Adam Dorey & Leeza Abraham & Yongzheng Xing & Irene Zhang & Fei Zhang & Stefan Howorka & Hao Yan, 2022. "A reversibly gated protein-transporting membrane channel made of DNA," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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