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The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

Author

Listed:
  • Beom Seok Park

    (Department of Chemistry and,)

  • Dong Hyun Song

    (Department of Chemistry and,)

  • Ho Min Kim

    (Department of Chemistry and,)

  • Byong-Seok Choi

    (Department of Chemistry and,)

  • Hayyoung Lee

    (School of Bioscience & Biotechnology, Chungnam National University, Daejeon, 305-764, Korea)

  • Jie-Oh Lee

    (Department of Chemistry and,
    Institute for the BioCentury, KAIST, Daejeon, 305-701, Korea)

Abstract

Innate immunity: LPS recognition This paper describes the crystal structure of TLR4-MD-2-LPS, the complex between Toll-like receptor 4, myeloid differentiation factor 2 and lipopolysaccharide (LPS).The structure reveals how the TLR4-MD-2-receptor complex recognizes LPS, a major component of the outer membrane of Gram negative bacteria that induces strong inflammatory responses by activating the human innate immune system. This work throws light on the important role of Toll-like receptor in innate immunity.

Suggested Citation

  • Beom Seok Park & Dong Hyun Song & Ho Min Kim & Byong-Seok Choi & Hayyoung Lee & Jie-Oh Lee, 2009. "The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex," Nature, Nature, vol. 458(7242), pages 1191-1195, April.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7242:d:10.1038_nature07830
    DOI: 10.1038/nature07830
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    Cited by:

    1. F. D. Kornilov & A. V. Shabalkina & Cong Lin & P. E. Volynsky & E. F. Kot & A. L. Kayushin & V. A. Lushpa & M. V. Goncharuk & A. S. Arseniev & S. A. Goncharuk & Xiaohui Wang & K. S. Mineev, 2023. "The architecture of transmembrane and cytoplasmic juxtamembrane regions of Toll-like receptors," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Ethan A. Older & Jian Zhang & Zachary E. Ferris & Dan Xue & Zheng Zhong & Mary K. Mitchell & Michael Madden & Yuzhen Wang & Hexin Chen & Prakash Nagarkatti & Mitzi Nagarkatti & Daping Fan & Melissa El, 2024. "Biosynthetic enzyme analysis identifies a protective role for TLR4-acting gut microbial sulfonolipids in inflammatory bowel disease," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Yoshihiro Hayashi & Yasushige Kamimura-Aoyagi & Sayuri Nishikawa & Rena Noka & Rika Iwata & Asami Iwabuchi & Yushin Watanabe & Natsumi Matsunuma & Kanako Yuki & Hiroki Kobayashi & Yuka Harada & Hirono, 2024. "IL36G-producing neutrophil-like monocytes promote cachexia in cancer," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    4. Martin Boström & Erik Larsson, 2022. "Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    5. Carsten Eriksen & Janne Marie Moll & Pernille Neve Myers & Ana Rosa Almeida Pinto & Niels Banhos Danneskiold-Samsøe & Rasmus Ibsen Dehli & Lisbeth Buus Rosholm & Marlene Danner Dalgaard & John Penders, 2023. "IgG and IgM cooperate in coating of intestinal bacteria in IgA deficiency," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    6. Kadi J. Horn & Melissa A. Schopper & Zoe G. Drigot & Sarah E. Clark, 2022. "Airway Prevotella promote TLR2-dependent neutrophil activation and rapid clearance of Streptococcus pneumoniae from the lung," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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