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Discovery of insect and human dengue virus host factors

Author

Listed:
  • October M. Sessions

    (Department of Molecular Genetics and Microbiology,
    Center for RNA Biology,)

  • Nicholas J. Barrows

    (Center for RNA Biology,
    Duke RNAi Facility,
    Institute for Genome Science and Policy,)

  • Jayme A. Souza-Neto

    (Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, Maryland 21205-2179, USA)

  • Timothy J. Robinson

    (Department of Molecular Genetics and Microbiology,
    Medical Scientist Training Program,
    Program in Molecular Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA)

  • Christine L. Hershey

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Mary A. Rodgers

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Jose L. Ramirez

    (Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, Maryland 21205-2179, USA)

  • George Dimopoulos

    (Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, Maryland 21205-2179, USA)

  • Priscilla L. Yang

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

  • James L. Pearson

    (Department of Molecular Genetics and Microbiology,
    Center for RNA Biology,
    Duke RNAi Facility,)

  • Mariano A. Garcia-Blanco

    (Department of Molecular Genetics and Microbiology,
    Center for RNA Biology,
    Duke RNAi Facility,
    Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School)

Abstract

Dengue fever virus infectivity Dengue fever is endemic in many countries in South and Southeast Asia, Africa and South America, and elsewhere it is an emerging threat. It is caused by one of four dengue viruses — DENV-1, 2, 3 and 4 — transmitted by Aedes sp. mosquitoes; there is no approved vaccine and no effective specific therapy. The dengue viruses are compact flaviviruses likely to require a large number of host factors, and knowledge of those factors could lead to the discovery of potential targets for drugs and new vector control strategies. Now by using a high-throughput RNAi screening approach in DENV-2-infected Drosophila cells — Drosophila is related to the vector species and more amenable to the tools of genomics — more than a hundred candidate dengue virus host factors have been identified, many of them also acting as host factors in human cells.

Suggested Citation

  • October M. Sessions & Nicholas J. Barrows & Jayme A. Souza-Neto & Timothy J. Robinson & Christine L. Hershey & Mary A. Rodgers & Jose L. Ramirez & George Dimopoulos & Priscilla L. Yang & James L. Pear, 2009. "Discovery of insect and human dengue virus host factors," Nature, Nature, vol. 458(7241), pages 1047-1050, April.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7241:d:10.1038_nature07967
    DOI: 10.1038/nature07967
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    Cited by:

    1. Linhui Hao & Qiuling He & Zhishi Wang & Mark Craven & Michael A Newton & Paul Ahlquist, 2013. "Limited Agreement of Independent RNAi Screens for Virus-Required Host Genes Owes More to False-Negative than False-Positive Factors," PLOS Computational Biology, Public Library of Science, vol. 9(9), pages 1-20, September.
    2. Raghuvir Viswanatha & Enzo Mameli & Jonathan Rodiger & Pierre Merckaert & Fabiana Feitosa-Suntheimer & Tonya M. Colpitts & Stephanie E. Mohr & Yanhui Hu & Norbert Perrimon, 2021. "Bioinformatic and cell-based tools for pooled CRISPR knockout screening in mosquitos," Nature Communications, Nature, vol. 12(1), pages 1-13, December.

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