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Tbx18 and the fate of epicardial progenitors

Author

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  • Vincent M. Christoffels

    (Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Meibergdreef 15 L2-108, 1105 AZ Amsterdam, The Netherlands)

  • Thomas Grieskamp

    († Institut für Molekularbiologie, OE5250, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. kispert.andreas@mh-hannover.de)

  • Julia Norden

    († Institut für Molekularbiologie, OE5250, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. kispert.andreas@mh-hannover.de)

  • Mathilda T. M. Mommersteeg

    (Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Meibergdreef 15 L2-108, 1105 AZ Amsterdam, The Netherlands)

  • Carsten Rudat

    († Institut für Molekularbiologie, OE5250, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. kispert.andreas@mh-hannover.de)

  • Andreas Kispert

    († Institut für Molekularbiologie, OE5250, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. kispert.andreas@mh-hannover.de)

Abstract

Arising from: C.-L. Cai et al. Nature 454, 104–108 (2008)10.1038/nature06969 ; Cai et al. reply Uncovering the origins of myocardial cells is important for understanding and treating heart diseases1,2. Cai et al.3 suggest that Tbx18-expressing epicardium provides a substantial contribution to myocytes in the ventricular septum and the atrial and ventricular walls. Here we show that the T-box transcription factor gene 18 (Tbx18) itself is expressed in the myocardium, showing that their genetic lineage tracing system does not allow conclusions of an epicardial origin of cardiomyocytes in vivo to be drawn.

Suggested Citation

  • Vincent M. Christoffels & Thomas Grieskamp & Julia Norden & Mathilda T. M. Mommersteeg & Carsten Rudat & Andreas Kispert, 2009. "Tbx18 and the fate of epicardial progenitors," Nature, Nature, vol. 458(7240), pages 8-9, April.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7240:d:10.1038_nature07916
    DOI: 10.1038/nature07916
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    Cited by:

    1. Elena Astanina & Gabriella Doronzo & Davide Corà & Francesco Neri & Salvatore Oliviero & Tullio Genova & Federico Mussano & Emanuele Middonti & Edoardo Vallariello & Chiara Cencioni & Donatella Valdem, 2022. "The TFEB-TGIF1 axis regulates EMT in mouse epicardial cells," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    2. Wei Feng & Abha Bais & Haoting He & Cassandra Rios & Shan Jiang & Juan Xu & Cindy Chang & Dennis Kostka & Guang Li, 2022. "Single-cell transcriptomic analysis identifies murine heart molecular features at embryonic and neonatal stages," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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