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Role of Jhdm2a in regulating metabolic gene expression and obesity resistance

Author

Listed:
  • Keisuke Tateishi

    (Howard Hughes Medical Institute,
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7295, USA
    Present address: Department of Gastroenterology, University of Tokyo Hospital, Japan.)

  • Yuki Okada

    (Howard Hughes Medical Institute,
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7295, USA)

  • Eric M. Kallin

    (Howard Hughes Medical Institute,
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7295, USA)

  • Yi Zhang

    (Howard Hughes Medical Institute,
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7295, USA)

Abstract

Weight control in mice The histone demethylase Jhdm2a/Kdm3a has an important role in nuclear hormone receptor-mediated gene activation and male germ cell development. Tateishi et al., using Jhdm2a-knockout mice, demonstrate that Jhdm2a also regulates expression of metabolic genes such as Ppara and Ucp1. In addition, the obese phenotype of the knockout mice indicates the demethylase is involved in regulation of weight control.

Suggested Citation

  • Keisuke Tateishi & Yuki Okada & Eric M. Kallin & Yi Zhang, 2009. "Role of Jhdm2a in regulating metabolic gene expression and obesity resistance," Nature, Nature, vol. 458(7239), pages 757-761, April.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7239:d:10.1038_nature07777
    DOI: 10.1038/nature07777
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    Cited by:

    1. Jisu Oh & Amy E. Riek & Kevin T. Bauerle & Adriana Dusso & Kyle P. McNerney & Ruteja A. Barve & Isra Darwech & Jennifer E. Sprague & Clare Moynihan & Rong M. Zhang & Greta Kutz & Ting Wang & Xiaoyun X, 2023. "Embryonic vitamin D deficiency programs hematopoietic stem cells to induce type 2 diabetes," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Hiroki Takahashi & Ge Yang & Takeshi Yoneshiro & Yohei Abe & Ryo Ito & Chaoran Yang & Junna Nakazono & Mayumi Okamoto-Katsuyama & Aoi Uchida & Makoto Arai & Hitomi Jin & Hyunmi Choi & Myagmar Tumenjar, 2022. "MYPT1-PP1β phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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