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Comprehensive polymorphism survey elucidates population structure of Saccharomyces cerevisiae

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  • Joseph Schacherer

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
    Present address: Department of Molecular Genetics, Genomics and Microbiology, Louis-Pasteur University and CNRS, UMR7156, Strasbourg 67083, France.)

  • Joshua A. Shapiro

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA)

  • Douglas M. Ruderfer

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA)

  • Leonid Kruglyak

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA)

Abstract

Of yeast and man Baker's yeast, Saccharomyces cerevisiae, is one of the best studied model organisms, and has been associated with human activity for thousands of years. Two papers published in the 19 March 2009 issue of Nature provide a picture of its population structure and its relationship with other yeasts. Liti et al. compare genome variation in S. cerevisiae isolates with its closest wild cousin, S. paradoxus, which has never been associated with human activity. They find that variation in S. paradoxus closely follows geographic borders; S. cerevisiae shows less differentiation, consistent with opportunities for cross-breeding, rather than a few distinct domestication events, as the main human influence. Schacherer et al. compare 63 S. cerevisiae isolates from different ecological niches and geographic locations. They find evidence for genetic differentiation of three distinct subgroups based on where the strains were isolated: from vineyards, sake and related fermentations and lab strains. Their data support the hypothesis that these three groups represent separate domestication events, and that S. cerevisiae as a whole is not domesticated.

Suggested Citation

  • Joseph Schacherer & Joshua A. Shapiro & Douglas M. Ruderfer & Leonid Kruglyak, 2009. "Comprehensive polymorphism survey elucidates population structure of Saccharomyces cerevisiae," Nature, Nature, vol. 458(7236), pages 342-345, March.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7236:d:10.1038_nature07670
    DOI: 10.1038/nature07670
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    Cited by:

    1. Hyosik Jang & Ian M Ehrenreich, 2012. "Genome-Wide Characterization of Genetic Variation in the Unicellular, Green Alga Chlamydomonas reinhardtii," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-9, July.
    2. Carole Camarasa & Isabelle Sanchez & Pascale Brial & Frédéric Bigey & Sylvie Dequin, 2011. "Phenotypic Landscape of Saccharomyces cerevisiae during Wine Fermentation: Evidence for Origin-Dependent Metabolic Traits," PLOS ONE, Public Library of Science, vol. 6(9), pages 1-12, September.
    3. J Roman Arguello & Carolina Sellanes & Yann Ru Lou & Robert A Raguso, 2013. "Can Yeast (S. cerevisiae) Metabolic Volatiles Provide Polymorphic Signaling?," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-12, August.
    4. Inês Mendes & Ricardo Franco-Duarte & Lan Umek & Elza Fonseca & João Drumonde-Neves & Sylvie Dequin & Blaz Zupan & Dorit Schuller, 2013. "Computational Models for Prediction of Yeast Strain Potential for Winemaking from Phenotypic Profiles," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-10, July.
    5. Masel, Joanna & Lyttle, David N., 2011. "The consequences of rare sexual reproduction by means of selfing in an otherwise clonally reproducing species," Theoretical Population Biology, Elsevier, vol. 80(4), pages 317-322.

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