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Intracortical circuits of pyramidal neurons reflect their long-range axonal targets

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Listed:
  • Solange P. Brown

    (Stanford University School of Medicine, 300 Pasteur Drive, Edwards Building, R314, Stanford, California 94305-5342, USA)

  • Shaul Hestrin

    (Stanford University School of Medicine, 300 Pasteur Drive, Edwards Building, R314, Stanford, California 94305-5342, USA)

Abstract

Cortical mapping: axons' long reach The cerebral cortex is often viewed as a sparsely connected network of neurons. Using quadruple whole-cell recordings, Solange Brown and Shaul Hestrin have now tested for synaptic connections among heterogeneous populations of cortical excitatory cells — pyramidal neurons. Their results reveal highly connected local circuits of neurons, each reflecting the neurons' long-range projections to a different brain region. The findings illustrate a diversity of dense cortical microcircuitry associated with the variety of information streams that produce our repertoire of behaviours and internal states.

Suggested Citation

  • Solange P. Brown & Shaul Hestrin, 2009. "Intracortical circuits of pyramidal neurons reflect their long-range axonal targets," Nature, Nature, vol. 457(7233), pages 1133-1136, February.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7233:d:10.1038_nature07658
    DOI: 10.1038/nature07658
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    Cited by:

    1. Yoav Printz & Pritish Patil & Mathias Mahn & Asaf Benjamin & Anna Litvin & Rivka Levy & Max Bringmann & Ofer Yizhar, 2023. "Determinants of functional synaptic connectivity among amygdala-projecting prefrontal cortical neurons in male mice," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Wei Zhao & Kevin G. Johnston & Honglei Ren & Xiangmin Xu & Qing Nie, 2023. "Inferring neuron-neuron communications from single-cell transcriptomics through NeuronChat," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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