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Continuous single-cell imaging of blood generation from haemogenic endothelium

Author

Listed:
  • Hanna M. Eilken

    (Institute of Stem Cell Research, Helmholtz Center Munich—German Research Center for Environmental Health (GmbH))

  • Shin-Ichi Nishikawa

    (Laboratory for Stem Cell Biology, RIKEN Center for Developmental Biology)

  • Timm Schroeder

    (Institute of Stem Cell Research, Helmholtz Center Munich—German Research Center for Environmental Health (GmbH))

Abstract

Blood lines How the blood system forms during embryonic development is a topic of intensive research, in part because of the potential importance of the process for regenerative medicine. Two main theories have emerged to explain the formation of the haematopoietic stem cells that eventually populate the adult born marrow. One idea is that the haematopoietic stem cell and the endothelial lineage arise independently from the mesoderm; the other is that some haematopoietic and endothelial lineages derive from a specialized progenitor called a haemangioblast. Three papers in this issue unify the two theories. Both are correct: the haemangioblast does generate haematopoietic cells, but via a haemogenic endothelium intermediate.

Suggested Citation

  • Hanna M. Eilken & Shin-Ichi Nishikawa & Timm Schroeder, 2009. "Continuous single-cell imaging of blood generation from haemogenic endothelium," Nature, Nature, vol. 457(7231), pages 896-900, February.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7231:d:10.1038_nature07760
    DOI: 10.1038/nature07760
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    Cited by:

    1. Geethika Arekatla & Stavroula Skylaki & David Corredor Suarez & Hartland Jackson & Denis Schapiro & Stefanie Engler & Markus Auler & German Camargo Ortega & Simon Hastreiter & Andreas Reimann & Dirk L, 2024. "Identification of an embryonic differentiation stage marked by Sox1 and FoxA2 co-expression using combined cell tracking and high dimensional protein imaging," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. C. Biben & T. S. Weber & K. S. Potts & J. Choi & D. C. Miles & A. Carmagnac & T. Sargeant & C. A. Graaf & K. A. Fennell & A. Farley & O. J. Stonehouse & M. A. Dawson & D. J. Hilton & S. H. Naik & S. T, 2023. "In vivo clonal tracking reveals evidence of haemangioblast and haematomesoblast contribution to yolk sac haematopoiesis," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Qiang Zhao & Young-Min Han & Ping Song & Zhixue Liu & Zuyi Yuan & Ming-Hui Zou, 2022. "Endothelial cell-specific expression of serine/threonine kinase 11 modulates dendritic cell differentiation," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    4. Daniel H Rapoport & Tim Becker & Amir Madany Mamlouk & Simone Schicktanz & Charli Kruse, 2011. "A Novel Validation Algorithm Allows for Automated Cell Tracking and the Extraction of Biologically Meaningful Parameters," PLOS ONE, Public Library of Science, vol. 6(11), pages 1-16, November.
    5. D. M. Jeziorska & E. A. J. Tunnacliffe & J. M. Brown & H. Ayyub & J. Sloane-Stanley & J. A. Sharpe & B. C. Lagerholm & C. Babbs & A. J. H. Smith & V. J. Buckle & D. R. Higgs, 2022. "On-microscope staging of live cells reveals changes in the dynamics of transcriptional bursting during differentiation," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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