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A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

Author

Listed:
  • Marina Cella

    (Washington University School of Medicine, St Louis, Missouri 63110, USA)

  • Anja Fuchs

    (Washington University School of Medicine, St Louis, Missouri 63110, USA)

  • William Vermi

    (Spedali Civili, University of Brescia)

  • Fabio Facchetti

    (Spedali Civili, University of Brescia)

  • Karel Otero

    (Washington University School of Medicine, St Louis, Missouri 63110, USA)

  • Jochen K. M. Lennerz

    (Washington University School of Medicine, St Louis, Missouri 63110, USA)

  • Jason M. Doherty

    (Washington University School of Medicine, St Louis, Missouri 63110, USA)

  • Jason C. Mills

    (Washington University School of Medicine, St Louis, Missouri 63110, USA)

  • Marco Colonna

    (Washington University School of Medicine, St Louis, Missouri 63110, USA)

Abstract

NK-22 cells: an anti-inflammatory role A previously unrecognized subset of human natural killer (NK) lymphocytes is reported. These 'NK-22' cells are selectively localized in tonsil and gut mucosa and, in contrast to conventional NK cells, are poorly cytotoxic and secrete little or no interferon. Rather, they specialize in the secretion of interleukin 22 (IL-22), IL-26 and leukaemia inhibitory factor, all of which have been implicated in the protection of epithelia. The properties of NK-22 cells are consistent with an anti-inflammatory response that may contribute to the maintenance of mucosal integrity.

Suggested Citation

  • Marina Cella & Anja Fuchs & William Vermi & Fabio Facchetti & Karel Otero & Jochen K. M. Lennerz & Jason M. Doherty & Jason C. Mills & Marco Colonna, 2009. "A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity," Nature, Nature, vol. 457(7230), pages 722-725, February.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7230:d:10.1038_nature07537
    DOI: 10.1038/nature07537
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    Cited by:

    1. Romain Marlin & Marion Duriez & Nadia Berkane & Claire de Truchis & Yoann Madec & Marie-Anne Rey-Cuille & Jean-Saville Cummings & Claude Cannou & Heloise Quillay & Françoise Barré-Sinoussi & Marie-Thé, 2012. "Dynamic Shift from CD85j/ILT-2 to NKG2D NK Receptor Expression Pattern on Human Decidual NK during the First Trimester of Pregnancy," PLOS ONE, Public Library of Science, vol. 7(1), pages 1-9, January.
    2. Angelika Schmalzl & Tamara Leupold & Lucas Kreiss & Maximilian Waldner & Sebastian Schürmann & Markus F. Neurath & Christoph Becker & Stefan Wirtz, 2022. "Interferon regulatory factor 1 (IRF-1) promotes intestinal group 3 innate lymphoid responses during Citrobacter rodentium infection," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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