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Interferon regulatory factor 1 (IRF-1) promotes intestinal group 3 innate lymphoid responses during Citrobacter rodentium infection

Author

Listed:
  • Angelika Schmalzl

    (Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg)

  • Tamara Leupold

    (Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg)

  • Lucas Kreiss

    (Friedrich-Alexander University Erlangen-Nürnberg)

  • Maximilian Waldner

    (Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg)

  • Sebastian Schürmann

    (Friedrich-Alexander University Erlangen-Nürnberg)

  • Markus F. Neurath

    (Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg
    FAU Erlangen-Nürnberg)

  • Christoph Becker

    (Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg
    FAU Erlangen-Nürnberg)

  • Stefan Wirtz

    (Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg
    FAU Erlangen-Nürnberg)

Abstract

Group 3 innate lymphoid cells (ILC3s) are crucial mediators of immunity and epithelial barrier function during immune responses against extracellular bacteria. Here, we identify Interferon regulatory factor 1 (IRF-1), a transcription factor previously associated with type 1 immunity, as an essential regulator of intestinal ILC3 accumulation and effector cytokine production. We demonstrate that IRF-1 is upregulated in the context of infection with the enteropathogen Citrobacter rodentium and that its presence is central for anatomical containment and prevention of pathogen dissemination. We furthermore show that IRF-1 is required in order for intestinal ILC3s to produce large amounts of the protective effector cytokine IL-22 early in the course of infection. On a molecular level, our data indicate that IRF-1 controls ILC3 numbers and their activation by direct transcriptional regulation of the IL-12Rβ1 chain, thereby allowing ILCs to physiologically respond to IL-23 stimulation.

Suggested Citation

  • Angelika Schmalzl & Tamara Leupold & Lucas Kreiss & Maximilian Waldner & Sebastian Schürmann & Markus F. Neurath & Christoph Becker & Stefan Wirtz, 2022. "Interferon regulatory factor 1 (IRF-1) promotes intestinal group 3 innate lymphoid responses during Citrobacter rodentium infection," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33326-5
    DOI: 10.1038/s41467-022-33326-5
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    1. Tegest Aychek & Alexander Mildner & Simon Yona & Ki-Wook Kim & Nardy Lampl & Shlomit Reich-Zeliger & Louis Boon & Nir Yogev & Ari Waisman & Daniel J. Cua & Steffen Jung, 2015. "IL-23-mediated mononuclear phagocyte crosstalk protects mice from Citrobacter rodentium-induced colon immunopathology," Nature Communications, Nature, vol. 6(1), pages 1-10, May.
    2. Ruaidhrí Jackson & Lina Kroehling & Alexandra Khitun & Will Bailis & Abigail Jarret & Autumn G. York & Omair M. Khan & J. Richard Brewer & Mathias H. Skadow & Coco Duizer & Christian C. D. Harman & Le, 2018. "The translation of non-canonical open reading frames controls mucosal immunity," Nature, Nature, vol. 564(7736), pages 434-438, December.
    3. Marina Cella & Anja Fuchs & William Vermi & Fabio Facchetti & Karel Otero & Jochen K. M. Lennerz & Jason M. Doherty & Jason C. Mills & Marco Colonna, 2009. "A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity," Nature, Nature, vol. 457(7230), pages 722-725, February.
    4. Paul R. Mangan & Laurie E. Harrington & Darrell B. O'Quinn & Whitney S. Helms & Daniel C. Bullard & Charles O. Elson & Robin D. Hatton & Sharon M. Wahl & Trenton R. Schoeb & Casey T. Weaver, 2006. "Transforming growth factor-β induces development of the TH17 lineage," Nature, Nature, vol. 441(7090), pages 231-234, May.
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    Cited by:

    1. Jiaqi Yan & Rajendra Bhadane & Meixin Ran & Xiaodong Ma & Yuanqiang Li & Dongdong Zheng & Outi M. H. Salo-Ahen & Hongbo Zhang, 2024. "Development of Aptamer-DNAzyme based metal-nucleic acid frameworks for gastric cancer therapy," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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