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Generation of a prostate from a single adult stem cell

Author

Listed:
  • Kevin G. Leong

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Bu-Er Wang

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Leisa Johnson

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Wei-Qiang Gao

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

Abstract

Regenerative medicine: prostate seeded by a single stem cell In mice exposed to repeated cycles of androgen deprivation and androgen replacement, the prostate gland shrinks and regenerates repeatedly. This suggested the existence of prostate stem cells; various cell-surface markers have been reported to identify candidate stem cells, however they are not specific for prostate stem cells. Leong et al. now report the identification of the cytokine receptor CD117 (also called c-kit or stem cell factor receptor) as a marker of a rare adult mouse prostate stem cell population. Using this marker, in combination with others, they isolate single cells that can generate a functioning prostate when transplanted into living mice.

Suggested Citation

  • Kevin G. Leong & Bu-Er Wang & Leisa Johnson & Wei-Qiang Gao, 2008. "Generation of a prostate from a single adult stem cell," Nature, Nature, vol. 456(7223), pages 804-808, December.
    • Handle: RePEc:nat:nature:v:456:y:2008:i:7223:d:10.1038_nature07427
    DOI: 10.1038/nature07427
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    Cited by:

    1. Maria De Falco & Vincenza Laforgia, 2021. "Combined Effects of Different Endocrine-Disrupting Chemicals (EDCs) on Prostate Gland," IJERPH, MDPI, vol. 18(18), pages 1-18, September.

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